Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bang Yeon Hwang | - |
| dc.contributor.author | Jeong Hyung Lee | - |
| dc.contributor.author | Tae Hyeon Koo | - |
| dc.contributor.author | Hang Sub Kim | - |
| dc.contributor.author | Young Soo Hong | - |
| dc.contributor.author | Jai Seup Ro | - |
| dc.contributor.author | Kyong Soon Lee | - |
| dc.contributor.author | Jung Joon Lee | - |
| dc.date.accessioned | 2017-04-19T08:58:54Z | - |
| dc.date.available | 2017-04-19T08:58:54Z | - |
| dc.date.issued | 2002 | - |
| dc.identifier.issn | 0032-0943 | - |
| dc.identifier.uri | 10.1055/s-2002-20250 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5776 | - |
| dc.description.abstract | Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8α-hydroxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (2) and 3-oxo-8α-methoxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri. | - |
| dc.publisher | Georg Thieme Verlag Kg | - |
| dc.title | Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells | - |
| dc.title.alternative | Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells | - |
| dc.type | Article | - |
| dc.citation.title | Planta Medica | - |
| dc.citation.number | 2 | - |
| dc.citation.endPage | 105 | - |
| dc.citation.startPage | 101 | - |
| dc.citation.volume | 68 | - |
| dc.contributor.affiliatedAuthor | Bang Yeon Hwang | - |
| dc.contributor.affiliatedAuthor | Jeong Hyung Lee | - |
| dc.contributor.affiliatedAuthor | Tae Hyeon Koo | - |
| dc.contributor.affiliatedAuthor | Hang Sub Kim | - |
| dc.contributor.affiliatedAuthor | Young Soo Hong | - |
| dc.contributor.affiliatedAuthor | Jung Joon Lee | - |
| dc.contributor.alternativeName | 황방연 | - |
| dc.contributor.alternativeName | 이정형 | - |
| dc.contributor.alternativeName | 구태현 | - |
| dc.contributor.alternativeName | 김항섭 | - |
| dc.contributor.alternativeName | 홍영수 | - |
| dc.contributor.alternativeName | 노재섭 | - |
| dc.contributor.alternativeName | 이경순 | - |
| dc.contributor.alternativeName | 이정준 | - |
| dc.identifier.bibliographicCitation | Planta Medica, vol. 68, no. 2, pp. 101-105 | - |
| dc.identifier.doi | 10.1055/s-2002-20250 | - |
| dc.subject.keyword | Compositae | - |
| dc.subject.keyword | Cyclooxygenase-2 | - |
| dc.subject.keyword | Furanoligularenone | - |
| dc.subject.keyword | Inducible nitric oxide synthase | - |
| dc.subject.keyword | Ligularia fischeri | - |
| dc.subject.keyword | NF-κB | - |
| dc.subject.keyword | Nitric oxide | - |
| dc.subject.keyword | Prostaglandin E2 | - |
| dc.subject.local | Compositae | - |
| dc.subject.local | compositae | - |
| dc.subject.local | Cyclooxygenase 2 | - |
| dc.subject.local | Cyclooxygenase-2 | - |
| dc.subject.local | Cyclooxygenase-2 (COX-2) | - |
| dc.subject.local | cyclooxygenase-2 | - |
| dc.subject.local | Furanoligularenone | - |
| dc.subject.local | Inducible nitric oxide synthase | - |
| dc.subject.local | Inducible nitric oxide synthase (iNOS) | - |
| dc.subject.local | Inducible nitric oxide synthease (iNOS) | - |
| dc.subject.local | INOS | - |
| dc.subject.local | iNOS | - |
| dc.subject.local | inducible nitric oxide synthase | - |
| dc.subject.local | inducible nnitric oxide synthase | - |
| dc.subject.local | Ligularia fischeri | - |
| dc.subject.local | NFkappaB | - |
| dc.subject.local | NFκB | - |
| dc.subject.local | Nf-κB | - |
| dc.subject.local | Nf-κb | - |
| dc.subject.local | Nuclear factor (NF)-κB | - |
| dc.subject.local | Nuclear factor kappa B | - |
| dc.subject.local | Nuclear factor kappaB | - |
| dc.subject.local | Nuclear factor κB | - |
| dc.subject.local | Nuclear factor κB (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappa B | - |
| dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappaB | - |
| dc.subject.local | Nuclear factor-κB | - |
| dc.subject.local | Nuclear factor-κb | - |
| dc.subject.local | NF-kB | - |
| dc.subject.local | NF-kappa B | - |
| dc.subject.local | NF-kappaB | - |
| dc.subject.local | NF-ΚB | - |
| dc.subject.local | NF-κ B | - |
| dc.subject.local | NF-κB | - |
| dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
| dc.subject.local | nuclear factor kappa B | - |
| dc.subject.local | nuclear factor κB | - |
| dc.subject.local | nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
| dc.subject.local | nuclear factor-κB | - |
| dc.subject.local | nuclear factorκB | - |
| dc.subject.local | NO | - |
| dc.subject.local | NO (Nitric oxide) | - |
| dc.subject.local | Nitric oxid | - |
| dc.subject.local | Nitric oxide | - |
| dc.subject.local | Nitric oxide (NO) | - |
| dc.subject.local | nitric oxide | - |
| dc.subject.local | nitric oxide (NO) | - |
| dc.subject.local | nitric oxide. | - |
| dc.subject.local | Prostaglandin E2 | - |
| dc.subject.local | Prostaglandin e2 | - |
| dc.subject.local | prostaglandin E2 | - |
| dc.description.journalClass | Y | - |
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