Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production

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Title
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production
Author(s)
Hui Zi Jin; Bang Yeon Hwang; Hang Sub Kim; Jeong Hyung Lee; Young Ho Kim; Jung Joon Lee
Bibliographic Citation
Journal of Natural Products, vol. 65, no. 1, pp. 89-91
Publication Year
2002
Abstract
Two new sesquiterpene esters, 1β,8β-diacetoxyl-6α,9α-difuroyloxydihydro-β- agarofuran (1) and 1β-acetoxyl-2β,6α,9α-trifuroyloxydihydro-β- agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-κB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-κB activation and nitric oxide production.
ISSN
0163-3864
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/np010428r
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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