Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits

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dc.contributor.authorSeon Min Jeon-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorMoon Kyoo Jang-
dc.contributor.authorYeon Hee Kim-
dc.contributor.authorKyung Tak Nam-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorYong Bok Park-
dc.contributor.authorMyung Sook Choi-
dc.date.accessioned2017-04-19T08:58:54Z-
dc.date.available2017-04-19T08:58:54Z-
dc.date.issued2002-
dc.identifier.issn0009-8981-
dc.identifier.uri10.1016/S0009-8981(01)00778-1ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5779-
dc.description.abstractBackground: Due to the strong evidence on the involvement of active oxygen species in a variety of disorders, the role of antioxidants against oxidative stress has recently received increased attention. Methods: Twenty male rabbits were served a high-cholesterol (HC, 5 g/kg diet) diet or high-cholesterol diet supplemented with naringin (0.5 g/kg diet) or probucol (0.5 g/kg diet) for 8 weeks to compare the antioxidative effects of the citrus bioflavonoid (naringin) and antioxidative cholesterol-lowering drug (probucol). Results: The plasma thiobarbituric acid-reactive substances (TBARS) concentration was not significantly different between the groups, whereas the hepatic TBARS concentration was significantly lower in the probucol group than in both normal and HC control or naringin group. Probucol and naringin supplementation led to an increase in the hepatic superoxide dismutase (SOD) and catalase (CAT) activities, and a decrease in the hepatic mitochondrial hydrogen peroxide (H2O2) content compared to the HC-control group. However, there was no difference in the cytosolic H2O2 content or cytosolic glutathion peroxidase (GSH-Px) activity in the liver between the groups. Both naringin and probucol supplements significantly increased the plasma vitamin E concentration compared to the HC-control group. As regards the antioxidant enzyme gene expressions, naringin significantly increased the expression of three antioxidant enzyme mRNAs compared to the HC-control group, whereas probucol significantly increased the only SOD mRNA expression. Conclusions: The probucol supplement was very potent in the antioxidative defense system, whereas naringin exhibited a comparable antioxidant capacity based on increasing the gene expressions in the antioxidant enzymes, while also increasing the hepatic SOD and CAT activities, sparing plasma vitamin E, and decreasing the hepatic mitochondrial H2O2 content.-
dc.publisherElsevier-
dc.titleComparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits-
dc.title.alternativeComparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits-
dc.typeArticle-
dc.citation.titleClinica Chimica Acta-
dc.citation.number1-
dc.citation.endPage190-
dc.citation.startPage181-
dc.citation.volume317-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName전선민-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName장문교-
dc.contributor.alternativeName김영희-
dc.contributor.alternativeName남경택-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationClinica Chimica Acta, vol. 317, no. 1, pp. 181-190-
dc.identifier.doi10.1016/S0009-8981(01)00778-1-
dc.subject.keywordAntioxidant enzyme-
dc.subject.keywordLipid peroxides-
dc.subject.keywordmRNA expression-
dc.subject.keywordNaringin-
dc.subject.keywordProbucol-
dc.subject.localantioxidant enzyme-
dc.subject.localAntioxidant enzymes-
dc.subject.localantioxidant enzymes-
dc.subject.localAnti-oxidant enzyme-
dc.subject.localAntioxidant enzyme-
dc.subject.localAntioxidant Enzymes-
dc.subject.localLipid peroxide-
dc.subject.localLipid peroxides-
dc.subject.localmRNA expression-
dc.subject.localNaringin-
dc.subject.localnaringin-
dc.subject.localProbucol-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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