A caspase inducing inhibitor isolated from Forsythiae fructus = 연교(Forsythiae fructus)로부터 분리한 caspase 유도 저해물질

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dc.contributor.authorJin Hee Kim-
dc.contributor.authorYung Hee Kho-
dc.contributor.authorMee Ree Kim-
dc.contributor.authorHyun A Kim-
dc.contributor.authorSang Myung Lee-
dc.contributor.authorChoong Hwan Lee-
dc.date.accessioned2017-04-19T08:58:55Z-
dc.date.available2017-04-19T08:58:55Z-
dc.date.issued2002-
dc.identifier.issn03676293-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5781-
dc.description.abstractDuring the screening of inhibitors of caspase-3 induction in U937 human monocytic leukemia cells from natural sources, Forsythiae fructus, which showed a high level of inhibition, was selected. And then, the compound was purified from the methanol extract using silica gel column chromatography and HPLC. The inhibitor was identified as rengyolone, by spectroscophic methods of ESI-MS, , , DEPT, and HMBC. Rengyolone showed inhibitory activity of caspase-3 induction, a major protease of apoptosis cascade, with an value of after 7 h of treatment in U937 cells. It also showed inhibitory activity of caspace-1 induction, with an value of after 40 h of treatment in D10S cells. In addition, it showed protective effect against cell death with an value of on U937 cells induced by etoposide after 24 h of treatment, but did not show any cytotoxicity at the same condition without etoposide, a caspase 3 inducing agent.-
dc.publisherSouth Korea-
dc.titleA caspase inducing inhibitor isolated from Forsythiae fructus = 연교(Forsythiae fructus)로부터 분리한 caspase 유도 저해물질-
dc.title.alternativeA caspase inducing inhibitor isolated from Forsythiae fructus-
dc.typeArticle-
dc.citation.titleKorean Journal of Food Science & Technology-
dc.citation.number1-
dc.citation.endPage117-
dc.citation.startPage114-
dc.citation.volume34-
dc.contributor.alternativeName김진희-
dc.contributor.alternativeName고영희-
dc.contributor.alternativeName김미리-
dc.contributor.alternativeName김현아-
dc.contributor.alternativeName이상명-
dc.contributor.alternativeName이충환-
dc.identifier.bibliographicCitationKorean Journal of Food Science & Technology, vol. 34, no. 1, pp. 114-117-
dc.subject.keywordapoptosis-
dc.subject.keywordrengyolone-
dc.subject.keywordetoposide-
dc.subject.keywordU937-
dc.subject.keywordD10S-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localrengyolone-
dc.subject.localetoposide-
dc.subject.localEtoposide-
dc.subject.localU937-
dc.subject.localD10S-
dc.description.journalClassN-
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