Effect of rutin and tannic acid supplements on cholesterol metabolism in rats

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dc.contributor.authorSun Young Park-
dc.contributor.authorSong Hae Bok-
dc.contributor.authorSoen Min Jeon-
dc.contributor.authorYong Bok Park-
dc.contributor.authorSoon Jae Lee-
dc.contributor.authorTae Sook Jeong-
dc.contributor.authorMyung Sook Choi-
dc.date.accessioned2017-04-19T08:58:57Z-
dc.date.available2017-04-19T08:58:57Z-
dc.date.issued2002-
dc.identifier.issn0271-5317-
dc.identifier.uri10.1016/S0271-5317(01)00398-0ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5800-
dc.description.abstractThis study was designed to test the lipid-lowering and antioxidative activities of two phenolic compounds, rutin and tannic acid. Three groups of rats were given a semisynthetic diet containing 1 g of cholesterol/kg for 5 wks. The control group only received a high cholesterol diet, whereas the other two groups received a diet including 1 g of rutin or 1 g of tannic acid/kg. The rutin and tannic acid both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those in the control. The hepatic HMG-CoA reductase activity was significantly lower in the tannic acid group than in the rutin group, while the hepatic ACAT activity was significantly lower in both the rutin and tannic groups compared to the control group. The overall potential of the antioxidant system was significantly enhanced by the rutin and tannic acid supplements as the plasma and hepatic TBARS levels were lowered while the hepatic SOD and GSH-Px activities were increased in the high-cholesterol fed rats. Furthermore, these results suggest that the supplementation of rutin and tannic acid promoted the excretion of fecal sterols, thereby leading to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.-
dc.publisherElsevier-
dc.titleEffect of rutin and tannic acid supplements on cholesterol metabolism in rats-
dc.title.alternativeEffect of rutin and tannic acid supplements on cholesterol metabolism in rats-
dc.typeArticle-
dc.citation.titleNutrition Research-
dc.citation.number3-
dc.citation.endPage295-
dc.citation.startPage283-
dc.citation.volume22-
dc.contributor.affiliatedAuthorSong Hae Bok-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName박선영-
dc.contributor.alternativeName복성해-
dc.contributor.alternativeName전선민-
dc.contributor.alternativeName박용복-
dc.contributor.alternativeName이순재-
dc.contributor.alternativeName정태숙-
dc.contributor.alternativeName최명숙-
dc.identifier.bibliographicCitationNutrition Research, vol. 22, no. 3, pp. 283-295-
dc.identifier.doi10.1016/S0271-5317(01)00398-0-
dc.subject.keywordACAT-
dc.subject.keywordAntioxidant enzymes-
dc.subject.keywordFecal sterols-
dc.subject.keywordHMG-CoA reductase-
dc.subject.keywordRutin-
dc.subject.keywordTannic acid-
dc.subject.localACAT (acyl-CoA: cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localcholesterol acytransferase (ACAT)-
dc.subject.localCholestrol Acyl Transferase (ACAT)-
dc.subject.localAcyl CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localACAT (Acyl-CoA:cholesterol acyltransferase)-
dc.subject.localAcyl-CoA:cholesterol acyltransferase-
dc.subject.localACAT-
dc.subject.localAcyl-CoA: cholesterol acyltransferase-
dc.subject.localacyl-CoA:cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-CoA: cholesterol acyltransferase (ACAT)-
dc.subject.localAcyl-coenzyme A: cholesterol acyltransferase (ACAT)-
dc.subject.localCholesterol acytransferase (ACAT)-
dc.subject.localcholestrol acyl transferase (ACAT)-
dc.subject.localantioxidant enzyme-
dc.subject.localAntioxidant enzymes-
dc.subject.localantioxidant enzymes-
dc.subject.localAnti-oxidant enzyme-
dc.subject.localAntioxidant enzyme-
dc.subject.localAntioxidant Enzymes-
dc.subject.localFecal sterols-
dc.subject.localfecal sterols-
dc.subject.localHMG-CoA reductase-
dc.subject.localrutin-
dc.subject.localRutin-
dc.subject.localTannic acid-
dc.subject.localtannic acid-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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