Antiviral, antimicrobial, and cytotoxic properties of peptavirins A and B produced by Apiocrea sp. 14T

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Title
Antiviral, antimicrobial, and cytotoxic properties of peptavirins A and B produced by Apiocrea sp. 14T
Author(s)
Woon Hyung Yeo; Bong Sik Yun; Young Sook Kim; Sang Jun Lee; Ick Dong Yoo; Kap Sig Kim; Eun Kyung Park; Jong Chull Lee; Young Ho Kim
Bibliographic Citation
Plant Pathology Journal, vol. 18, no. 1, pp. 18-22
Publication Year
2002
Abstract
Two peptaibol antibiotics, peptavirins A and B, which exhibited strong inhibitory effect against Tobacco mosaic vials (TMV) infection, were isolated from steam-cooked rice culture of Apiocrea sp.14T. The peptavirins were identified as new derivatives of chrysospermins, which are 19-mer and have been reported to be produced in a fungal isolate. The physicochemical properties of the peptavirins were mostly identical with chrysospermins A through D except for the UV absorption spectrum. The peptavirins inhibited the growths of the Grampositive bacteria tested, including the plant pathogenic bacterium, Corynebacterium lilium, and the fungus, Aspergillus niger. Peptavirin A was somewhat cytotoxic to cancer cell lines, especially K562 (leukemia) and UACC 62 (melanoma), whereas peptavirin B only exhibited slight cytotoxicity.
Keyword
antimicrobial activityapiocrea sp.cytotoxicitypeptavirinspeptaibol antibiotics
ISSN
I000-0113
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5423/PPJ.2002.18.1.018
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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