Antiviral, antimicrobial, and cytotoxic properties of peptavirins A and B produced by Apiocrea sp. 14T
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- Antiviral, antimicrobial, and cytotoxic properties of peptavirins A and B produced by Apiocrea sp. 14T
- Woon Hyung Yeo; Bong Sik Yun; Young Sook Kim; Sang Jun Lee; Ick Dong Yoo; Kap Sig Kim; Eun Kyung Park; Jong Chull Lee; Young Ho Kim
- Bibliographic Citation
- Plant Pathology Journal, vol. 18, no. 1, pp. 18-22
- Publication Year
- Two peptaibol antibiotics, peptavirins A and B, which exhibited strong inhibitory effect against Tobacco mosaic vials (TMV) infection, were isolated from steam-cooked rice culture of Apiocrea sp.14T. The peptavirins were identified as new derivatives of chrysospermins, which are 19-mer and have been reported to be produced in a fungal isolate. The physicochemical properties of the peptavirins were mostly identical with chrysospermins A through D except for the UV absorption spectrum. The peptavirins inhibited the growths of the Grampositive bacteria tested, including the plant pathogenic bacterium, Corynebacterium lilium, and the fungus, Aspergillus niger. Peptavirin A was somewhat cytotoxic to cancer cell lines, especially K562 (leukemia) and UACC 62 (melanoma), whereas peptavirin B only exhibited slight cytotoxicity.
- antimicrobial activityapiocrea sp.cytotoxicitypeptavirinspeptaibol antibiotics
- Korea Soc-Assoc-Inst
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- 1. Journal Articles > Journal Articles
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