DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang Kyu Choi | - |
dc.contributor.author | Byung Il Yoon | - |
dc.contributor.author | Yoon Hoh Kook | - |
dc.contributor.author | Young Suk Won | - |
dc.contributor.author | Jin Hyun Kim | - |
dc.contributor.author | Chul Ho Lee | - |
dc.contributor.author | Byung Hwa Hyun | - |
dc.contributor.author | Goo Taeg Oh | - |
dc.contributor.author | John Sipley | - |
dc.contributor.author | Dae Yong Kim | - |
dc.date.accessioned | 2017-04-19T08:59:01Z | - |
dc.date.available | 2017-04-19T08:59:01Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0910-5050 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5823 | - |
dc.description.abstract | The significance of urokinase-type plasminogen activator (uPA) expression in gastric cancer development was tested by using a human uPA cDNA transfection approach and an in vivo severe combined immunodeficient (SCID) mouse model. The AGS gastric cancer cell line, which has urokinase-type plasminogen-activator receptor (uPAR) but lacks uPA, was transfected with a plasmid containing human uPA cDNA and injected into the backs of SCID mice. Compared with the parent AGS cells, uPA protein secretion in AGS-2-, AGS-4-, and AGS-8-transfected cells increased by 26.1-, 34.6-, and 4.8-fold, respectively (P<0.05). mRNA expression levels of uPA in the AGS-4 clone were much stronger than those in AGS-2 and AGS-8 clones. After the cancer cells (2×106) were injected s.c. into the SCID mice, a palpable mass was observed at the injection site at around 140 days post-injection, followed by accelerated growth of the xenograft up to 180 days post-injection only in the high uPA-producing clone (AGS-4). These results suggest that continuous and high production of uPA by tumor cells is one of the important factors reflecting the malignancy of gastric cancer cells. | - |
dc.title | Overexpression of urokinase-type plasminogen activator in human gastric cancer cell line (AGS) induces tumorigenicity in severe combined immunodeficient mice | - |
dc.title.alternative | Overexpression of urokinase-type plasminogen activator in human gastric cancer cell line (AGS) induces tumorigenicity in severe combined immunodeficient mice | - |
dc.type | Article | - |
dc.citation.title | Japanese Journal of Cancer Research | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 156 | - |
dc.citation.startPage | 151 | - |
dc.citation.volume | 93 | - |
dc.contributor.affiliatedAuthor | Yang Kyu Choi | - |
dc.contributor.affiliatedAuthor | Young Suk Won | - |
dc.contributor.affiliatedAuthor | Chul Ho Lee | - |
dc.contributor.affiliatedAuthor | Byung Hwa Hyun | - |
dc.contributor.affiliatedAuthor | Goo Taeg Oh | - |
dc.contributor.alternativeName | 최양규 | - |
dc.contributor.alternativeName | 윤병일 | - |
dc.contributor.alternativeName | 국윤호 | - |
dc.contributor.alternativeName | 원영석 | - |
dc.contributor.alternativeName | 김진현 | - |
dc.contributor.alternativeName | 이철호 | - |
dc.contributor.alternativeName | 현병화 | - |
dc.contributor.alternativeName | 오구택 | - |
dc.contributor.alternativeName | Sipley | - |
dc.contributor.alternativeName | 김대용 | - |
dc.identifier.bibliographicCitation | Japanese Journal of Cancer Research, vol. 93, no. 2, pp. 151-156 | - |
dc.identifier.doi | 10.1111/j.1349-7006.2002.tb01253.x | - |
dc.subject.keyword | AGS | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | SCID | - |
dc.subject.keyword | transfection | - |
dc.subject.keyword | uPA | - |
dc.subject.local | AGS | - |
dc.subject.local | gastric cancer | - |
dc.subject.local | Gastric cancer (GC) | - |
dc.subject.local | Gastric cancer | - |
dc.subject.local | SCID | - |
dc.subject.local | Transfection | - |
dc.subject.local | transfection | - |
dc.subject.local | UPA | - |
dc.subject.local | uPA | - |
dc.description.journalClass | N | - |
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