Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

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dc.contributor.authorChoong Hwan Lee-
dc.contributor.authorHyun A Kim-
dc.contributor.authorYung Hee Kho-
dc.date.accessioned2017-04-19T08:59:01Z-
dc.date.available2017-04-19T08:59:01Z-
dc.date.issued2002-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/np010425eko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5824-
dc.description.abstractInvestigation of the whole plant of Agastache rugosa resulted in the isolation of two new lignan compounds. Their structures were elucidated as (8S, 7′R, 8′S)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)2-(4-hydroxy-3-methoxyphenyl) tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7′R, 8′S)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)- tetrahydrofuran-3ylmethyl ester (agastenol, 2). Agastinol and agastenol inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 15.2 and 11.4μg/mL, respectively.-
dc.publisherAmer Chem Soc-
dc.titleAgastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay-
dc.title.alternativeAgastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number3-
dc.citation.endPage416-
dc.citation.startPage414-
dc.citation.volume65-
dc.contributor.affiliatedAuthorChoong Hwan Lee-
dc.contributor.affiliatedAuthorHyun A Kim-
dc.contributor.affiliatedAuthorYung Hee Kho-
dc.contributor.alternativeName이충환-
dc.contributor.alternativeName김현아-
dc.contributor.alternativeName고영희-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 65, no. 3, pp. 414-416-
dc.identifier.doi10.1021/np010425e-
dc.description.journalClassY-
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