Novel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation

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dc.contributor.authorHung Bae Chang-
dc.contributor.authorSun Ho Kim-
dc.contributor.authorYoung In Kwon-
dc.contributor.authorDong Ho Choung-
dc.contributor.authorWon Kyu Choi-
dc.contributor.authorTae Won Kang-
dc.contributor.authorSung Sook Lee-
dc.contributor.authorJong Gwan Kim-
dc.contributor.authorHyoung Sik Chun-
dc.contributor.authorSoon Kil Ahn-
dc.contributor.authorChung Il Hong-
dc.contributor.authorKyou Hoon Han-
dc.date.accessioned2017-04-19T08:59:02Z-
dc.date.available2017-04-19T08:59:02Z-
dc.date.issued2002-
dc.identifier.issn0021-8820-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5829-
dc.description.abstractWe have isolated two novel α-glucosidase inhibitors, O-[4-deoxy-4-(2,3-epoxy-3-hydroxymethyl-4,5,6-trihydroxycyclohexane- 1-y1-amino)-α-D-glucopyranosyl]- (1→4)-O-α-D-glucopyranosyl- (1→4)-α-D-glucopyranose (named CKD-711) and its hexameric analog CKD-711a, from the fermentation broth of Streptomyces sp. CK-4416. HRFAB-MS and NMR analyses reveal that molecular formulae of CKD-711 and CKD-711a are C25H43NO20 and C37H63NO30, respectively with the latter containing two more glucose moieties than the former. Detailed chemical structures of both compounds have been characterized by high-resolution two-dimensional NMR methods.-
dc.publisherSpringer-Nature Pub Group-
dc.titleNovel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation-
dc.title.alternativeNovel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation-
dc.typeArticle-
dc.citation.titleJournal of Antibiotics-
dc.citation.number5-
dc.citation.endPage471-
dc.citation.startPage467-
dc.citation.volume55-
dc.contributor.affiliatedAuthorDong Ho Choung-
dc.contributor.affiliatedAuthorKyou Hoon Han-
dc.contributor.alternativeName장흥배-
dc.contributor.alternativeName김선호-
dc.contributor.alternativeName권영인-
dc.contributor.alternativeName정동호-
dc.contributor.alternativeName최원규-
dc.contributor.alternativeName강태원-
dc.contributor.alternativeName이성숙-
dc.contributor.alternativeName김종관-
dc.contributor.alternativeName천형식-
dc.contributor.alternativeName안순길-
dc.contributor.alternativeName홍정일-
dc.contributor.alternativeName한규훈-
dc.identifier.bibliographicCitationJournal of Antibiotics, vol. 55, no. 5, pp. 467-471-
dc.identifier.doi10.7164/antibiotics.55.467-
dc.description.journalClassY-
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