Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy

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Title
Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy
Author(s)
In Won Chung; Nicholas A Moore; Won Keun Oh; Michael F O'Neill; Jong Seog Ahn; Joo Bae Park; Ung Gu Kang; Yong Sik Kim
Bibliographic Citation
Pharmacology Biochemistry and Behavior, vol. 71, no. 1, pp. 191-195
Publication Year
2002
Abstract
Polygalasaponins were extracted from a plant (Polygala tenuifolia Willdenow) that has been prescribed for hundreds of years to treat psychotic illnesses in Korean traditional medicine. Previous in vitro binding studies suggested a potential mechanism for its antipsychotic action, as polygalasaponin was shown to have an affinity for both dopamine and serotonin receptors [Psychopharmacol. Bull. 31 (1995) 139.]. In the present study we have investigated the functional in vivo actions of this material in tests that are predictive of dopamine and serotonin antagonist activities. Polygalasaponin (25-500 mg/kg) was shown to produce a dose-related reduction in the apomorphine-induced climbing behaviour (minimum effective dose [EDmin] 25 mg/kg ip, 250 mg/kg sc and po), the 5-hydroxytryptamine (5-HTP)-induced serotonin syndrome (EDmin 50 mg/kg ip) and the MK-801-induced hyperactivity (EDmin 25 mg/kg ip) in mice. This compound also reduced the cocaine-induced hyperactivity (EDmin 25 mg/kg ip) in rats. These results demonstrated that polygalasaponin has dopamine and serotonin receptor antagonist properties in vivo. This might suggest its possible utility as an antipsychotic agent.
Keyword
AntipsychoticsBehavioural pharmacologyClimbing behaviourDopaminePolygalasaponinSerotonin
ISSN
0091-3057
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0091-3057(01)00648-7
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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