Synthesis and anti-tumor activity of novel combretastatins : combretocyclopentenones and related analogues

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Title
Synthesis and anti-tumor activity of novel combretastatins : combretocyclopentenones and related analogues
Author(s)
Nguyen Hai Nam; Yong Kim; Young Jae You; Dong Ho Hong; Hwan Mook Kim; Byung Zun Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 15, pp. 1955-1958
Publication Year
2002
Abstract
A series of 2-(3,4,5-trimethoxyphenyl)-3-arylcyclopent-2-ene-1-ones (8a-8e) and their related analogues, including pentenone 9a, pentenol 10a, pentene 12a, and furane 15, were synthesized and evaluated for cytotoxicity against murine and human tumor cell lines. Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC50 values in the range of 8-34 ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%.
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0960-894X(02)00321-9
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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