Aceriphyllic acid A, a new ACAT inhibitory triterpenoid, from Aceriphyllum rossii

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Title
Aceriphyllic acid A, a new ACAT inhibitory triterpenoid, from Aceriphyllum rossii
Author(s)
Jae Taek Han; Hae Yeong Kim; Young Doo Park; Youn Hyung Lee; Kang Ro Lee; Byoung-Mog Kwon; Nam In Baek
Bibliographic Citation
Planta Medica, vol. 68, no. 6, pp. 558-561
Publication Year
2002
Abstract
Two new triterpenoids along with three known ones, 3-oxo-olean-12-en-27-oic acid (1), 3α-hydroxyolean-12-en-27-oic acid (2) and 3β-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3α,23-dihydroxyolean-12-en-27-oic acid (4) and a 3α,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2002-32565
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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