The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata = 천마(Gastrodia elata)로부터 분리한 VHR DS-PTPase 저해 물질

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dc.contributor.authorMyung Sun Lee-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorEun Young Bae-
dc.contributor.authorSoon Cheol Ahn-
dc.contributor.authorCheon Bae Sohn-
dc.contributor.authorHiroyuki Osada-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T08:59:06Z-
dc.date.available2017-04-19T08:59:06Z-
dc.date.issued2002-
dc.identifier.issn0367-6293-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5858-
dc.description.abstractIn the course of screening program for VHR DS-PTPase (dual-specificity protein tyrosine phosphatase) from natural sources, Gastrodia elata was selected. One compound showing potent inhibitory activity was isolated by the solvent extraction and column chromatography including silica gel, ODS RP-18, Sephades LH-20, and HPLC. This compound was identified as baicalein by several NMR techniques such as , , and DEPT. Baicalein showed selective inhibitory activity against VHR DS-PTPase with , and showed cytotoxicity against several human cancer cell lines with an of range, including, melanoma (LOX-IMVI), lung cancer (NCI H23 and A549), colon cancer (HCT 116 and SW 620), prostate cancer (PC-3), and leukemia (MOLT 4F).-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata = 천마(Gastrodia elata)로부터 분리한 VHR DS-PTPase 저해 물질-
dc.title.alternativeThe VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata-
dc.typeArticle-
dc.citation.titleKorean Journal of Food Science & Technology-
dc.citation.number3-
dc.citation.endPage509-
dc.citation.startPage505-
dc.citation.volume34-
dc.contributor.affiliatedAuthorMyung Sun Lee-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorEun Young Bae-
dc.contributor.affiliatedAuthorSoon Cheol Ahn-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이명선-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName배은영-
dc.contributor.alternativeName안순철-
dc.contributor.alternativeName손천배-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationKorean Journal of Food Science & Technology, vol. 34, no. 3, pp. 505-509-
dc.subject.keywordgastrodia elata-
dc.subject.keywordVHR DS-PTPase-
dc.subject.keywordbaicalein-
dc.subject.keywordcytotoxicity-
dc.subject.localgastrodia elata-
dc.subject.localGastrodia elata-
dc.subject.localVHR DS-PTPase-
dc.subject.localbaicalein-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.description.journalClassN-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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