DC Field | Value | Language |
---|---|---|
dc.contributor.author | Myung Sun Lee | - |
dc.contributor.author | Won Keun Oh | - |
dc.contributor.author | Eun Young Bae | - |
dc.contributor.author | Soon Cheol Ahn | - |
dc.contributor.author | Cheon Bae Sohn | - |
dc.contributor.author | Hiroyuki Osada | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T08:59:06Z | - |
dc.date.available | 2017-04-19T08:59:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0367-6293 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5858 | - |
dc.description.abstract | In the course of screening program for VHR DS-PTPase (dual-specificity protein tyrosine phosphatase) from natural sources, Gastrodia elata was selected. One compound showing potent inhibitory activity was isolated by the solvent extraction and column chromatography including silica gel, ODS RP-18, Sephades LH-20, and HPLC. This compound was identified as baicalein by several NMR techniques such as , , and DEPT. Baicalein showed selective inhibitory activity against VHR DS-PTPase with , and showed cytotoxicity against several human cancer cell lines with an of range, including, melanoma (LOX-IMVI), lung cancer (NCI H23 and A549), colon cancer (HCT 116 and SW 620), prostate cancer (PC-3), and leukemia (MOLT 4F). | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata = 천마(Gastrodia elata)로부터 분리한 VHR DS-PTPase 저해 물질 | - |
dc.title.alternative | The VHR Dual-Specificity Protein Tyrosine Phosphatase (DS-PTPase) inhibitor isolated from Gastrodia elata | - |
dc.type | Article | - |
dc.citation.title | Korean Journal of Food Science & Technology | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 509 | - |
dc.citation.startPage | 505 | - |
dc.citation.volume | 34 | - |
dc.contributor.affiliatedAuthor | Myung Sun Lee | - |
dc.contributor.affiliatedAuthor | Won Keun Oh | - |
dc.contributor.affiliatedAuthor | Eun Young Bae | - |
dc.contributor.affiliatedAuthor | Soon Cheol Ahn | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 이명선 | - |
dc.contributor.alternativeName | 오원근 | - |
dc.contributor.alternativeName | 배은영 | - |
dc.contributor.alternativeName | 안순철 | - |
dc.contributor.alternativeName | 손천배 | - |
dc.contributor.alternativeName | Osada | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Korean Journal of Food Science & Technology, vol. 34, no. 3, pp. 505-509 | - |
dc.subject.keyword | gastrodia elata | - |
dc.subject.keyword | VHR DS-PTPase | - |
dc.subject.keyword | baicalein | - |
dc.subject.keyword | cytotoxicity | - |
dc.subject.local | gastrodia elata | - |
dc.subject.local | Gastrodia elata | - |
dc.subject.local | VHR DS-PTPase | - |
dc.subject.local | baicalein | - |
dc.subject.local | Cytotoxicity | - |
dc.subject.local | cytotoxicity | - |
dc.description.journalClass | N | - |
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