Atroviridins A~C and neoatroviridins A~D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317 : 1. taxonomy, fermentation, isolation and biological activities

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Title
Atroviridins A~C and neoatroviridins A~D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317 : 1. taxonomy, fermentation, isolation and biological activities
Author(s)
Seung Uk Oh; Bong Sik Yun; Sang Jun Lee; Jung Han Kim; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 55, no. 6, pp. 557-564
Publication Year
2002
Abstract
Seven new peptaibols, atroviridins A-C composed of 20 residue amino acids and neoatroviridins A-D with 18 residues, were isolated from the culture broth of fungal strain F80317. The strain F80317 was identified as Trichoderma atroviride from its morphological and cultural characteristics. These compounds showed antimicrobial activity against Gram-positive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.55.557
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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