Cross-resistance between rifampicin and KRM-1648 is associated with specific rpoB alleles in Mycobacterium tuberculosis

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Title
Cross-resistance between rifampicin and KRM-1648 is associated with specific rpoB alleles in Mycobacterium tuberculosis
Author(s)
Y K Park; B J Kim; S Ryu; Y H Kook; Yong Kyung Choe; G H Bai; S J Kim
Bibliographic Citation
International Journal of Tuberculosis and Lung Disease, vol. 6, no. 2, pp. 166-170
Publication Year
2002
Abstract
KRM-1648 resistant Mycobacterium tuberculosis strains were identified from a collection of rifampicin-resistant strains. Several strains had novel rpoB gene mutations in codons 512, 529 and 533 of the rpoB gene. The strains with mutations in codons 526 or 531, major mutation sites in rifampicin-resistant M. tuberculosis, were resistant to KRM-1648. Also, the strains with other mutations in the rpoB gene that were initially susceptible to KRM-1648 were prone to developing KRM-1648 resistance after further mutation. Thus, KRM-1648 is unlikely to be useful for the treatment of rifampicin-resistant tuberculosis.
Keyword
cross-resistanceKRM-1648M. tuberculosisrifampicinRpoB gene
ISSN
1027-3719
Publisher
Int Union Against Tuberculosis Lung Disease (I U A T L D)
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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