Screening of Korean medicinal and food plants with antitumoral activity = 국내 약용 및 식용식물중 항종양활성 식물탐색

Abstract

This study was conducted to screen antitumoral activity by in vitro bioassay method using 60 Korean medicinal and food plants extracted by 80% EtOH. Antitumor activity test was applied by the PKC(protein kinase C) and antibleb formation, PLC(Phospholipase C), and colorimetric tetrazolium assay(MTT assay) methods. Chenopodium album and black Glycine max showed high antitumoral activity by 73.5% and 81.0%, respectively, against PKC by bleb-forming assay and PKC enzyme assay on human chronic leukemia K562 cell. Black Glycine max also showed 91.2% antitumoral activity in the PLC method and the lowest IC_(50) value (4.7㎍/㎖) by MTT method against P-338 cell line. In the effect of the concentration treatment on antitumoral test, the more concentration indicated the more activity value.