Hepatitis B virus X protein induced expression of interleukin 18 (IL-18) : a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection

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dc.contributor.authorM O Lee-
dc.contributor.authorY H Choi-
dc.contributor.authorE C Shin-
dc.contributor.authorH J Kang-
dc.contributor.authorY M Kim-
dc.contributor.authorS Y Jeong-
dc.contributor.authorJ K Seong-
dc.contributor.authorDae Yeul Yu-
dc.contributor.authorH S Cho-
dc.contributor.authorJ H Park-
dc.contributor.authorS J Kim-
dc.date.accessioned2017-04-19T08:59:12Z-
dc.date.available2017-04-19T08:59:12Z-
dc.date.issued2002-
dc.identifier.issn0168-8278-
dc.identifier.uri10.1016/S0168-8278(02)00181-2ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5890-
dc.description.abstractBackground/Aims: The hepatitis B virus X protein (HBx), a major viral transactivator, is implicated in hepatic inflammation, since it induces many pro-inflammatory cytokines at transcriptional level. The aim of this study was to investigate role of HBx in expression of interleukin 18 (IL-18), a newly identified cytokine that up-regulates Fas ligand (FasL) expression. Methods: Chang X-34 that expressing HBx under the control of a doxycycline-inducible promoter, and hepatitis B virus (HBV)-integrated hepatoma cell lines were examined for IL-18 expression by Northern and Western blotting analysis. To test the role of IL-18 produced by hepatoma cells, FasL expression was examined by flow cytometry after treatment with neutralizing anti-IL-18 antibodies. Further, IL-18 expression was examined in the liver tissues of HBx-transgenic mice. Results: Induction of IL-18 following HBx expression in Chang X-34 and the pattern of IL-18 expression in HBV-integrated cell lines, implicated that HBx transcriptionally induces IL-18 expression. Neutralizing anti-IL-18 antibodies blocked the expression of FasL, suggesting that IL-18 plays a critical role in FasL expression. Further, IL-18 expression in the HBx-transgenic liver, was correlated with the degree of hepatitis. Conclusions: Our results demonstrated that HBx induces IL-18 expression in liver, which may be associated with hepatic injury by amplifying FasL expression during HBV infection.-
dc.publisherElsevier-
dc.titleHepatitis B virus X protein induced expression of interleukin 18 (IL-18) : a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection-
dc.title.alternativeHepatitis B virus X protein induced expression of interleukin 18 (IL-18) : a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection-
dc.typeArticle-
dc.citation.titleJournal of Hepatology-
dc.citation.number3-
dc.citation.endPage386-
dc.citation.startPage380-
dc.citation.volume37-
dc.contributor.affiliatedAuthorDae Yeul Yu-
dc.contributor.alternativeName이미옥-
dc.contributor.alternativeName최연희-
dc.contributor.alternativeName신의철-
dc.contributor.alternativeName강효진-
dc.contributor.alternativeName김영미-
dc.contributor.alternativeName정수연-
dc.contributor.alternativeName성제경-
dc.contributor.alternativeName유대열-
dc.contributor.alternativeName조혜성-
dc.contributor.alternativeName박전한-
dc.contributor.alternativeName김세종-
dc.identifier.bibliographicCitationJournal of Hepatology, vol. 37, no. 3, pp. 380-386-
dc.identifier.doi10.1016/S0168-8278(02)00181-2-
dc.subject.keywordFas ligand-
dc.subject.keywordHepatitis B virus X protein-
dc.subject.keywordInterleukin 18-
dc.subject.keywordLiver injury-
dc.subject.localFas ligand-
dc.subject.localhepatitis B virus X protein-
dc.subject.localHepatitis B virus-X protein-
dc.subject.localHepatitis B virus X protein-
dc.subject.localhepatitis B virus-X protein-
dc.subject.localHepatitis B virus X-protein-
dc.subject.localInterleukin 18 (IL-18)-
dc.subject.localInterleukin 18-
dc.subject.localLiver injury-
dc.description.journalClassY-
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