DC Field | Value | Language |
---|---|---|
dc.contributor.author | M O Lee | - |
dc.contributor.author | Y H Choi | - |
dc.contributor.author | E C Shin | - |
dc.contributor.author | H J Kang | - |
dc.contributor.author | Y M Kim | - |
dc.contributor.author | S Y Jeong | - |
dc.contributor.author | J K Seong | - |
dc.contributor.author | Dae Yeul Yu | - |
dc.contributor.author | H S Cho | - |
dc.contributor.author | J H Park | - |
dc.contributor.author | S J Kim | - |
dc.date.accessioned | 2017-04-19T08:59:12Z | - |
dc.date.available | 2017-04-19T08:59:12Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | 10.1016/S0168-8278(02)00181-2 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5890 | - |
dc.description.abstract | Background/Aims: The hepatitis B virus X protein (HBx), a major viral transactivator, is implicated in hepatic inflammation, since it induces many pro-inflammatory cytokines at transcriptional level. The aim of this study was to investigate role of HBx in expression of interleukin 18 (IL-18), a newly identified cytokine that up-regulates Fas ligand (FasL) expression. Methods: Chang X-34 that expressing HBx under the control of a doxycycline-inducible promoter, and hepatitis B virus (HBV)-integrated hepatoma cell lines were examined for IL-18 expression by Northern and Western blotting analysis. To test the role of IL-18 produced by hepatoma cells, FasL expression was examined by flow cytometry after treatment with neutralizing anti-IL-18 antibodies. Further, IL-18 expression was examined in the liver tissues of HBx-transgenic mice. Results: Induction of IL-18 following HBx expression in Chang X-34 and the pattern of IL-18 expression in HBV-integrated cell lines, implicated that HBx transcriptionally induces IL-18 expression. Neutralizing anti-IL-18 antibodies blocked the expression of FasL, suggesting that IL-18 plays a critical role in FasL expression. Further, IL-18 expression in the HBx-transgenic liver, was correlated with the degree of hepatitis. Conclusions: Our results demonstrated that HBx induces IL-18 expression in liver, which may be associated with hepatic injury by amplifying FasL expression during HBV infection. | - |
dc.publisher | Elsevier | - |
dc.title | Hepatitis B virus X protein induced expression of interleukin 18 (IL-18) : a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection | - |
dc.title.alternative | Hepatitis B virus X protein induced expression of interleukin 18 (IL-18) : a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection | - |
dc.type | Article | - |
dc.citation.title | Journal of Hepatology | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 386 | - |
dc.citation.startPage | 380 | - |
dc.citation.volume | 37 | - |
dc.contributor.affiliatedAuthor | Dae Yeul Yu | - |
dc.contributor.alternativeName | 이미옥 | - |
dc.contributor.alternativeName | 최연희 | - |
dc.contributor.alternativeName | 신의철 | - |
dc.contributor.alternativeName | 강효진 | - |
dc.contributor.alternativeName | 김영미 | - |
dc.contributor.alternativeName | 정수연 | - |
dc.contributor.alternativeName | 성제경 | - |
dc.contributor.alternativeName | 유대열 | - |
dc.contributor.alternativeName | 조혜성 | - |
dc.contributor.alternativeName | 박전한 | - |
dc.contributor.alternativeName | 김세종 | - |
dc.identifier.bibliographicCitation | Journal of Hepatology, vol. 37, no. 3, pp. 380-386 | - |
dc.identifier.doi | 10.1016/S0168-8278(02)00181-2 | - |
dc.subject.keyword | Fas ligand | - |
dc.subject.keyword | Hepatitis B virus X protein | - |
dc.subject.keyword | Interleukin 18 | - |
dc.subject.keyword | Liver injury | - |
dc.subject.local | Fas ligand | - |
dc.subject.local | hepatitis B virus X protein | - |
dc.subject.local | Hepatitis B virus-X protein | - |
dc.subject.local | Hepatitis B virus X protein | - |
dc.subject.local | hepatitis B virus-X protein | - |
dc.subject.local | Hepatitis B virus X-protein | - |
dc.subject.local | Interleukin 18 (IL-18) | - |
dc.subject.local | Interleukin 18 | - |
dc.subject.local | Liver injury | - |
dc.description.journalClass | Y | - |
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