Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
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- Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
- Ha Won Jeong; Ho Jae Lee; Yung Hee Kho; Kwang Hee Son; Mi Young Han; Jong-Seok Lim; Mi Young Lee; Dong Cho Han; J H Ha; Byoung-Mog Kwon
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry, vol. 10, no. 10, pp. 3129-3134
- Publication Year
- Sesquicillin, isolated from fumgal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21Waf1/Cip1, was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by swsquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21Waf1/Cip1, and the reduction of G1 phase related-cyclin proteins.
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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