Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
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- Title
- Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
- Author(s)
- Ha Won Jeong; Ho Jae Lee; Yung Hee Kho; Kwang Hee Son; Mi Young Han; Jong-Seok Lim; Mi Young Lee; Dong Cho Han; J H Ha; Byoung-Mog Kwon
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry, vol. 10, no. 10, pp. 3129-3134
- Publication Year
- 2002
- Abstract
- Sesquicillin, isolated from fumgal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21Waf1/Cip1, was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by swsquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21Waf1/Cip1, and the reduction of G1 phase related-cyclin proteins.
- ISSN
- 0968-0896
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/S0968-0896(02)00225-0
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Genomic Medicine Research Center > 1. Journal Articles
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