Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines

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Title
Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines
Author(s)
Ha Won Jeong; Ho Jae Lee; Yung Hee Kho; Kwang Hee Son; Mi Young Han; Jong-Seok Lim; Mi Young Lee; Dong Cho Han; J H Ha; Byoung-Mog Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 10, no. 10, pp. 3129-3134
Publication Year
2002
Abstract
Sesquicillin, isolated from fumgal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21Waf1/Cip1, was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by swsquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21Waf1/Cip1, and the reduction of G1 phase related-cyclin proteins.
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0968-0896(02)00225-0
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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