Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1

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Title
Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1
Author(s)
Kyung Seop AhnJung Hee KimSei Ryang Oh; Byung Sun Min; J Kinjo; Hyeong Kyu Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 25, no. 8, pp. 1105-1107
Publication Year
2002
Abstract
We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-α-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the same activity as dexamethasone. On the other hand, the absence of hydroxyl group at C-24 position of sapogenin rather to increase ICAM-1 expression compared with the untreated control. We concluded that the activity of oleanane saponins and sapogenins against ICAM-1 expression are dependent upon the position of the hydroxyl group, and in particular upon the status of the C-21 and C-24 positions and of the glycosyl group at C-3 position.
Keyword
Fabaceous plantIntercellular adhesion moleculeOleanane-type triterpenoid
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.25.1105
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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