Aberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts

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dc.contributor.authorDeog Bon Koo-
dc.contributor.authorYong Kook Kang-
dc.contributor.authorYoung Hee Choi-
dc.contributor.authorJung Sun Park-
dc.contributor.authorH N Kim-
dc.contributor.authorK B Oh-
dc.contributor.authorD S Son-
dc.contributor.authorH Park-
dc.contributor.authorKyung Kwang Lee-
dc.contributor.authorYong Mahn Han-
dc.date.accessioned2017-04-19T08:59:14Z-
dc.date.available2017-04-19T08:59:14Z-
dc.date.issued2002-
dc.identifier.issn00063363-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5900-
dc.description.abstractAbortions of nuclear transfer (NT) embryos are mainly due to insufficient placentation. We hypothesized that the primary cause might be the aberrant allocations of two different cell lineages of the blastocyst stage embryos, the inner cell mass (ICM) and the trophectoderm (TE) cells. The potential for development of NT embryos to blastocysts was similar to that for in vitro fertilized (IVF) embryos. No difference in the total cell number was detected between NT and IVF blastocysts, but both types of embryos had fewer total cells than did in vivo-derived embryos (P < 0.05). The NT blastocysts showed a higher ratio of ICM:total cells than did IVF or in vivo-derived embryos (P < 0.05). Individual blastocysts were assigned to four subgroups (1: <20%, II: 20-40%, III: 40-60%, IV: >60%) according to the ratio of ICM:total cells. Most NT blastocysts were placed in groups III and IV, whereas most IVF and in vivo-derived blastocysts were distributed in group II. Our findings suggest that placental abnormalities or early fetal losses in the present cloning system may be due to aberrant allocations of NT embryos to the ICM and TE cells-during early development.-
dc.publisherOxford Univ Press-
dc.titleAberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts-
dc.title.alternativeAberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts-
dc.typeArticle-
dc.citation.titleBiology of Reproduction-
dc.citation.number2-
dc.citation.endPage492-
dc.citation.startPage487-
dc.citation.volume67-
dc.contributor.affiliatedAuthorYong Kook Kang-
dc.contributor.affiliatedAuthorJung Sun Park-
dc.contributor.alternativeName구덕본-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName최영희-
dc.contributor.alternativeName박정선-
dc.contributor.alternativeName김하나-
dc.contributor.alternativeName오근봉-
dc.contributor.alternativeName손동수-
dc.contributor.alternativeName박흠대-
dc.contributor.alternativeName이경광-
dc.contributor.alternativeName한용만-
dc.identifier.bibliographicCitationBiology of Reproduction, vol. 67, no. 2, pp. 487-492-
dc.identifier.doi10.1095/biolreprod67.2.487-
dc.subject.keyworddevelopmental biology-
dc.subject.keywordearly development-
dc.subject.keywordembryo-
dc.subject.keywordimplantation-
dc.subject.keywordtrophoblast-
dc.subject.localdevelopmental biology-
dc.subject.localearly development-
dc.subject.localEarly development-
dc.subject.localembryo-
dc.subject.localEmbryo-
dc.subject.localimplantation-
dc.subject.localImplantation-
dc.subject.localtrophoblast-
dc.subject.localTrophoblast-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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