Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis

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dc.contributor.authorH J Jung-
dc.contributor.authorByung Sun Min-
dc.contributor.authorJ Y Park-
dc.contributor.authorY H Kim-
dc.contributor.authorHyeong Kyu Lee-
dc.contributor.authorK H Bae-
dc.date.accessioned2017-04-19T08:59:14Z-
dc.date.available2017-04-19T08:59:14Z-
dc.date.issued2002-
dc.identifier.issn0163-3864-
dc.identifier.uri10.1021/np0104018ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5904-
dc.description.abstractSix new polyacetylenes, gymnasterkoreaynes A-F (1-6), were isolated from the roots of Gymnaster koraiensis, together with 2,9,16-heptadecatrien-4,6-diyn-8-ol (7) and 1,9,16-heptadecatriene-4,6-diyn-3,8-diol (8), by bioassay-guided fractionation using the L1210 tumor cell line as a model for cytotoxicity. The structures of compounds 1-6 were established spectroscopically, which included 2D NMR experiments. Gymnasterkoreaynes A-F (1-6) are linear diacetylenes and are structurally related to falcarinol, panaxynol, panaxydiol, and panaxytriol. of the compounds isolated, gymnasterkoreaynes B (2), C (3), F (6), and 1,9,16-heptadecatrien-4,6-diyn-3,8-diol (8) exhibited significant cytotoxicity against L1210 tumor cells with ED50 values of 0.12-3.3 μg/mL.-
dc.publisherAmer Chem Soc-
dc.titleGymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis-
dc.title.alternativeGymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number6-
dc.citation.endPage901-
dc.citation.startPage897-
dc.citation.volume65-
dc.contributor.affiliatedAuthorByung Sun Min-
dc.contributor.affiliatedAuthorHyeong Kyu Lee-
dc.contributor.alternativeName정현주-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName박진영-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName이형규-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 65, no. 6, pp. 897-901-
dc.identifier.doi10.1021/np0104018-
dc.description.journalClassY-
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