Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor(VEGF)-induced tube formation of HUVECs

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Title
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor(VEGF)-induced tube formation of HUVECs
Author(s)
Hee Jung Lee; Jeong Hyeong Lee; Bang Yeon Hwang; Hang Sub Kim; Jung Joon Lee
Bibliographic Citation
Journal of Antibiotics, vol. 55, no. 6, pp. 552-556
Publication Year
2002
Abstract
In the search for new naturally occurring anti-angiogenic compounds, we found that a culture broth of an unidentified fungal strain B90911 exerted inhibitory activity on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Four active compounds were isolated by bioassay-guided separation and their structures were identified to be sulochrin (1), methyl asterric acid (2), and two new asterric acid derivatives, 3-chloroasterric acid (3), and 3,5-dichloroasterric acid (4) by spectroscopic analyses. These compounds significantly inhibited the VEGF-induced tube formation of HUVEC, suggesting that asterric derivatives could be useful for further study as anti-angiogenic agents.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.55.552
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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