S100A6 protein as a marker for differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma

Cited 28 time in scopus
Metadata Downloads
Title
S100A6 protein as a marker for differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma
Author(s)
Jae Wha Kim; J H Kim; Sun Young Yoon; Joung Hyuck Joo; Yong Hee Lee; K S Lee; J H Chung; In Seong Choe
Bibliographic Citation
Hepatology Research, vol. 23, no. 4, pp. 274-286
Publication Year
2002
Abstract
A new marker useful for differential diagnosis of cholangiocarcinoma (CC) from hepatocellular carcinoma (HCC) has been identified and investigated. cDNA clone for S100A6 (calcyclin) was identified as a upregulated gene in intrahepatic tumors by differential dot hybridization and Northern blot analysis using normal and tumor intrahepatic tissues. Significant increase in the expression level of S100A6 mRNA was recognized in intrahepatic tissues in three of three CC cases but none of six primary HCC. Immunohistochemical examination of the tumor tissues using monoclonal antibody specific to S100A6 showed that 14 of 18 (77.8%) CC tissue samples were positively stained but only two of 20 (10%) specimens from the patients with primary HCC were weakly stained. These results suggest that the levels of S100A6 mRNA expression and protein in the tissue specimens examined by Northern blot and immunohistochemical staining may be additional useful marker for the differentiation of CC from HCC.
Keyword
cholangiocarcinomahepatocellular carcinomamarker for differential diagnosisS100A6
ISSN
1386-6346
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/S1386-6346(02)00008-6
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.