Etoposide activates caspase-3 via a caspase-1 independent mechanism in cancer cells

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Title
Etoposide activates caspase-3 via a caspase-1 independent mechanism in cancer cells
Author(s)
Sang-Han Lee; Kyu Tae Chang; O Y Kwon; T K Kwon
Bibliographic Citation
Experimental Oncology, vol. 24, no. 2, pp. 105-107
Publication Year
2002
Abstract
It is known that caspase-1 is activated before caspase-3 activation when the cells were treated with anti-Fas-antibody. In present study the activities of these two proteases in etoposide-treated cells were examined. It has been shown that whilst treatment of U937 and Jurkat cells with etoposide results in caspase-3 activation it did not influence caspase-1 activity. At the same time treatment of U937 cells with anti-Fas antibody induces caspase-1 activity. These results demonstrate that etoposide transmits the death signal to caspase-3 directly, suggesting that caspase-3 was activated by a caspase-1 independent mechanism during etoposide-induced apoptosis.
Keyword
apoptosiscaspase-1caspase-3etoposide
ISSN
0204-3564
Publisher
Korean Society for Brain and Neural Science
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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