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- Title
- Etoposide activates caspase-3 via a caspase-1 independent mechanism in cancer cells
- Author(s)
- Sang-Han Lee; Kyu Tae Chang; O Y Kwon; T K Kwon
- Bibliographic Citation
- Experimental Oncology, vol. 24, no. 2, pp. 105-107
- Publication Year
- 2002
- Abstract
- It is known that caspase-1 is activated before caspase-3 activation when the cells were treated with anti-Fas-antibody. In present study the activities of these two proteases in etoposide-treated cells were examined. It has been shown that whilst treatment of U937 and Jurkat cells with etoposide results in caspase-3 activation it did not influence caspase-1 activity. At the same time treatment of U937 cells with anti-Fas antibody induces caspase-1 activity. These results demonstrate that etoposide transmits the death signal to caspase-3 directly, suggesting that caspase-3 was activated by a caspase-1 independent mechanism during etoposide-induced apoptosis.
- Keyword
- apoptosiscaspase-1caspase-3etoposide
- ISSN
- 0204-3564
- Publisher
- Korean Society for Brain and Neural Science
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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