Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jeong Suk Ko | - |
| dc.contributor.author | S Y Ryu | - |
| dc.contributor.author | Y S Kim | - |
| dc.contributor.author | Mi Yeon Chung | - |
| dc.contributor.author | J S Kang | - |
| dc.contributor.author | Mun Chual, Rho | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | Young Kook Kim | - |
| dc.date.accessioned | 2017-04-19T08:59:17Z | - |
| dc.date.available | 2017-04-19T08:59:17Z | - |
| dc.date.issued | 2002 | - |
| dc.identifier.issn | 0253-6269 | - |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5919 | - |
| dc.description.abstract | The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 μg/ml and 11.1 μg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 μg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity. | - |
| dc.publisher | Pharmaceutical Soc Korea | - |
| dc.title | Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza | - |
| dc.title.alternative | Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza | - |
| dc.type | Article | - |
| dc.citation.title | Archives of Pharmacal Research | - |
| dc.citation.number | 4 | - |
| dc.citation.endPage | 448 | - |
| dc.citation.startPage | 446 | - |
| dc.citation.volume | 25 | - |
| dc.contributor.affiliatedAuthor | Jeong Suk Ko | - |
| dc.contributor.affiliatedAuthor | Mi Yeon Chung | - |
| dc.contributor.affiliatedAuthor | Mun Chual, Rho | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.affiliatedAuthor | Young Kook Kim | - |
| dc.contributor.alternativeName | 고정숙 | - |
| dc.contributor.alternativeName | 유시용 | - |
| dc.contributor.alternativeName | 김영섭 | - |
| dc.contributor.alternativeName | 정미연 | - |
| dc.contributor.alternativeName | 강종성 | - |
| dc.contributor.alternativeName | 노문철 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 김영국 | - |
| dc.identifier.bibliographicCitation | Archives of Pharmacal Research, vol. 25, no. 4, pp. 446-448 | - |
| dc.identifier.doi | 10.1007/bf02976599 | - |
| dc.subject.keyword | diacylglycerol acyltransferase | - |
| dc.subject.keyword | labiatae | - |
| dc.subject.keyword | salvia miltiorrhiza | - |
| dc.subject.keyword | tanshinones | - |
| dc.subject.local | diacylglycerol acyltansferase (DGAT) | - |
| dc.subject.local | diacylglycerol acyltransferase | - |
| dc.subject.local | Diacylglycerol acyltransferase | - |
| dc.subject.local | Diacylglycerol acyltransferase (DGAT) | - |
| dc.subject.local | Labiatae | - |
| dc.subject.local | labiatae | - |
| dc.subject.local | salvia miltiorrhiza | - |
| dc.subject.local | salvia mitiorrhiza | - |
| dc.subject.local | Tanshinone | - |
| dc.subject.local | tanshinones | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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