Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi

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dc.contributor.authorSeung Ho Lee-
dc.contributor.authorHyae Kyeong Kim-
dc.contributor.authorJeong Min Seo-
dc.contributor.authorHyun Mi Kang-
dc.contributor.authorJong Han Kim-
dc.contributor.authorKwang Hee Son-
dc.contributor.authorH S Lee-
dc.contributor.authorByoung-Mog Kwon-
dc.contributor.authorJ H Shin-
dc.contributor.authorY W Seo-
dc.date.accessioned2017-04-19T08:59:18Z-
dc.date.available2017-04-19T08:59:18Z-
dc.date.issued2002-
dc.identifier.issn0022-3263-
dc.identifier.uri10.1021/jo020299zko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5931-
dc.description.abstractArteminolides B-D (2-4), new farnesyl protein transferase inhibitors, were isolated together with a known arteminolide A (1) and new regioisomers (5-7) of the compounds from the aerial parts of Artemisia argyi. Structures of these compounds were elucidated by spectroscopic methods and chemical conversion. Arteminolides inhibited the farnesyl protein transferase with IC50 values of 0.7-1/ μM, while the regioisomers 5-7 were inactive. In addition, it was proved that the exocyclic double bond of sesquiterpene lactone did not affect the inhibitory activity of arteminolide. The effects of compound 2 on H-Ras processing and cellular growth in H-ras-transformed cells were also evaluated.-
dc.publisherAmer Chem Soc-
dc.titleArteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi-
dc.title.alternativeArteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi-
dc.typeArticle-
dc.citation.titleJournal of Organic Chemistry-
dc.citation.number22-
dc.citation.endPage7675-
dc.citation.startPage7670-
dc.citation.volume67-
dc.contributor.affiliatedAuthorSeung Ho Lee-
dc.contributor.affiliatedAuthorHyae Kyeong Kim-
dc.contributor.affiliatedAuthorJeong Min Seo-
dc.contributor.affiliatedAuthorHyun Mi Kang-
dc.contributor.affiliatedAuthorJong Han Kim-
dc.contributor.affiliatedAuthorKwang Hee Son-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName이승호-
dc.contributor.alternativeName김혜경-
dc.contributor.alternativeName서정민-
dc.contributor.alternativeName강현미-
dc.contributor.alternativeName김종한-
dc.contributor.alternativeName손광희-
dc.contributor.alternativeName이희순-
dc.contributor.alternativeName권병목-
dc.contributor.alternativeName신종헌-
dc.contributor.alternativeName서영완-
dc.identifier.bibliographicCitationJournal of Organic Chemistry, vol. 67, no. 22, pp. 7670-7675-
dc.identifier.doi10.1021/jo020299z-
dc.description.journalClassY-
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Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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