DC Field | Value | Language |
---|---|---|
dc.contributor.author | J S Lee | - |
dc.contributor.author | Byung Sun Min | - |
dc.contributor.author | Sang Myung Lee | - |
dc.contributor.author | M K Na | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.contributor.author | C O Lee | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | K H Bae | - |
dc.date.accessioned | 2017-04-19T08:59:18Z | - |
dc.date.available | 2017-04-19T08:59:18Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5932 | - |
dc.description.abstract | Eight sesquiterpene lactones, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 μM) against all tumor call lines tested. Among these compounds, 4α, 5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 μM) comparable to that of cisplatin. | - |
dc.publisher | Georg Thieme Verlag Kg | - |
dc.title | Cytotoxic sesquiterpene lactones form Carpesium abrotanoides | - |
dc.title.alternative | Cytotoxic sesquiterpene lactones form Carpesium abrotanoides | - |
dc.type | Article | - |
dc.citation.title | Planta Medica | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 747 | - |
dc.citation.startPage | 745 | - |
dc.citation.volume | 68 | - |
dc.contributor.affiliatedAuthor | Byung Sun Min | - |
dc.contributor.affiliatedAuthor | Sang Myung Lee | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 이준성 | - |
dc.contributor.alternativeName | 민병선 | - |
dc.contributor.alternativeName | 이상명 | - |
dc.contributor.alternativeName | 나민균 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.contributor.alternativeName | 이종옥 | - |
dc.contributor.alternativeName | 김영호 | - |
dc.contributor.alternativeName | 배기환 | - |
dc.identifier.bibliographicCitation | Planta Medica, vol. 68, no. 7, pp. 745-747 | - |
dc.identifier.doi | 10.1055/s-2002-33789 | - |
dc.description.journalClass | Y | - |
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