Isolation of Acyl-CoA:Cholesterol Acyltransferase inhibitor from Persicaria vulgaris

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Title
Isolation of Acyl-CoA:Cholesterol Acyltransferase inhibitor from Persicaria vulgaris
Author(s)
Hye Young Song; Mun Chual RhoSeung Woong Lee; Oh Eok Kwon; Y D Chang; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Planta Medica, vol. 68, no. 9, pp. 845-847
Publication Year
2002
Abstract
In the course of our search for Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from the methanol extract of Persicaria vulgaris. On the basis of spectral evidence, the structure of the active compound was identified as pheophorbide A. Pheophorbide A inhibited ACAT activity with an IC50 value of 1.1 μg/ml in an enzyme assay using rat liver microsomes with a dose dependent fashion.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2002-34395
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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