Eucosterol oligoglycosides isolated from Scilla scilloides and their anti-tumor activity

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Title
Eucosterol oligoglycosides isolated from Scilla scilloides and their anti-tumor activity
Author(s)
Sang Myung Lee; Hyo Kon Chun; Choong Hwan Lee; Byung Sun Min; E S Lee; Yung Hee Kho
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 50, no. 9, pp. 1245-1249
Publication Year
2002
Abstract
Two new eucosterol oligoglycosides, 15-deoxo-30-hydroxyeucosterol 3-O-α-L-rhamnopyranosyl-(1→2)-[( β-Dglucopyranosyl-(1→3)]- β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→6) -β-D-glucopyranoside (scillanoside L-1, 1) and 3 β,31-dihydroxy-17 α,23-epoxy-5α-lanost-8-en-23,26-olactone 3-O- α-L- rhamnopyranosyl-(1→2)-[ β-D-glucopyranosyl-(1→3)]- β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→6) -β-D-glucopyranoside (scillanoside L-2, 2), were isolated from the bulbs of Scilla scilloides, together with four that were known (3-6), have been isolated from the bulbs of Scilla scilloides. The structures of the new compounds were determined on the basis of spectroscopic and chromatographic methods, and some chemical transformations were discussed. Amongst the isolated compounds, 3 showed the most significant cytotoxicity against tumor cells tested several types with ED50 value of 1.53-3.06 nM. In vivo experiments, 3 apparently increased the life span of mice bearing Sarcoma 180 tumor cell with T/C value of 239% at dose of 3 mg/kg.
Keyword
anti-tumor activityscilla scilloidesspirocyclic nortriterpenoide
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.50.1245
Type
Article
Appears in Collections:
Division of Bio Technology Innovation > SME Support Center > 1. Journal Articles
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