New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells

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Title
New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells
Author(s)
J J Gao; Byung Sun Min; E M Ahn; N Nakamura; Hyeong Kyu Lee; M Hattori
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 50, no. 6, pp. 837-840
Publication Year
2002
Abstract
Three new lanostante-type triterpene aldehydes, named lucialdehydes A - C (1 - 3), were isolated from the fruiting bodies of Ganoderma lucidum, together with ganodermanonol (4), ganodermadiol (5), ganodermanondiol (6), ganodermanontriol (7), ganoderic acid A (8), ganoderic acid B8 (9), and ganoderic acid C1 (10). The structures of the new triterpenes were determined as (24E)-3β-hydroxy-5α-lanosta-7,9(11),24-trien-26-al (1), (24E)-3,7-dioxo-5α-lanosta-8,24-dien-26-al (2), and (24E)-3β-hydroxy- 7-oxo-5α-lanosta-8,24-dien-26-al (3), respectively, by spectroscopic means. The cytotoxicity of the compounds isolated from the ganoderma mushroom was tested in vitro against Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. Lucialdehydes B, C (2, 3), ganodermanonol (4) and ganodermanondiol (6) showed cytotoxic effects on tested tumor cells. of the compounds, lucialdehyde C (3) exhibited the most potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED50 values of 10.7, 4.7, 7.1, and 3.8 μg/ml, respectively.
Keyword
CytotoxicityGanoderma lucidumLanostane-type triterpene aldehydeLucialdehyde A - C
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.50.837
Type
Article
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1. Journal Articles > Journal Articles
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