DC Field | Value | Language |
---|---|---|
dc.contributor.author | N D Sung | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T08:59:28Z | - |
dc.date.available | 2017-04-19T08:59:28Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0368-2897 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/5987 | - |
dc.description.abstract | Characteristic stereostructures of famesyl protein transferase(FPTase) inhibition matcrials isolated from Artemisia sylvatica and regioselectivity of biogenic Diels-Alder reactions between dehydromatricarin molecules A and B were examined quantitatively. Results revealed that the major reaction of frontief molecular orbital(FMO) interaction proceeds through charge-control reaction between LUMO of A16, dienophile and HOMO of B1, diene, and the isolated 8-acetylarteminolide and artanomaloide were minor products. FPTase inhibition activity and hydrophobicity of 8-acetylarteminolide were pI_50=3.75 and logp=2.62, respectively. FPTase inhibition activity of 8-acetylarteminolide was higher than those of artanomaloide and dehydromatricarin. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Characteristic stereostructures and regioselectivity of biogenic pathway of FPTase inhibition materials isolated from Artemisia sylvatica = 그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 FPTase 저해활성 물질들의 구조적인 특성과 biogenic pathway의 배향성 | - |
dc.title.alternative | Characteristic stereostructures and regioselectivity of biogenic pathway of FPTase inhibition materials isolated from Artemisia sylvatica | - |
dc.type | Article | - |
dc.citation.title | Journal of Korean Society of Agricul Chem Biot | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 227 | - |
dc.citation.startPage | 223 | - |
dc.citation.volume | 45 | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 성낙도 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Agricul Chem Biot, vol. 45, no. 4, pp. 223-227 | - |
dc.subject.keyword | FPTase inhibition materials | - |
dc.subject.keyword | artemisia sylvatica Max. | - |
dc.subject.keyword | biogenic Diels-Alder reaction | - |
dc.subject.keyword | frontier molecular orbital (FMO) interaction | - |
dc.subject.keyword | regioselectivity | - |
dc.subject.local | FPTase inhibition materials | - |
dc.subject.local | artemisia sylvatica Max. | - |
dc.subject.local | biogenic Diels-Alder reaction | - |
dc.subject.local | frontier molecular orbital (FMO) interaction | - |
dc.subject.local | Regioselectivity | - |
dc.subject.local | regioselectivity | - |
dc.description.journalClass | N | - |
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.