Characteristic stereostructures and regioselectivity of biogenic pathway of FPTase inhibition materials isolated from Artemisia sylvatica = 그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 FPTase 저해활성 물질들의 구조적인 특성과 biogenic pathway의 배향성

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dc.contributor.authorN D Sung-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T08:59:28Z-
dc.date.available2017-04-19T08:59:28Z-
dc.date.issued2002-
dc.identifier.issn0368-2897-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5987-
dc.description.abstractCharacteristic stereostructures of famesyl protein transferase(FPTase) inhibition matcrials isolated from Artemisia sylvatica and regioselectivity of biogenic Diels-Alder reactions between dehydromatricarin molecules A and B were examined quantitatively. Results revealed that the major reaction of frontief molecular orbital(FMO) interaction proceeds through charge-control reaction between LUMO of A16, dienophile and HOMO of B1, diene, and the isolated 8-acetylarteminolide and artanomaloide were minor products. FPTase inhibition activity and hydrophobicity of 8-acetylarteminolide were pI_50=3.75 and logp=2.62, respectively. FPTase inhibition activity of 8-acetylarteminolide was higher than those of artanomaloide and dehydromatricarin.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleCharacteristic stereostructures and regioselectivity of biogenic pathway of FPTase inhibition materials isolated from Artemisia sylvatica = 그늘쑥(Artemisia sylvatica Max.)으로부터 분리된 FPTase 저해활성 물질들의 구조적인 특성과 biogenic pathway의 배향성-
dc.title.alternativeCharacteristic stereostructures and regioselectivity of biogenic pathway of FPTase inhibition materials isolated from Artemisia sylvatica-
dc.typeArticle-
dc.citation.titleJournal of Korean Society of Agricul Chem Biot-
dc.citation.number4-
dc.citation.endPage227-
dc.citation.startPage223-
dc.citation.volume45-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName성낙도-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationJournal of Korean Society of Agricul Chem Biot, vol. 45, no. 4, pp. 223-227-
dc.subject.keywordFPTase inhibition materials-
dc.subject.keywordartemisia sylvatica Max.-
dc.subject.keywordbiogenic Diels-Alder reaction-
dc.subject.keywordfrontier molecular orbital (FMO) interaction-
dc.subject.keywordregioselectivity-
dc.subject.localFPTase inhibition materials-
dc.subject.localartemisia sylvatica Max.-
dc.subject.localbiogenic Diels-Alder reaction-
dc.subject.localfrontier molecular orbital (FMO) interaction-
dc.subject.localregioselectivity-
dc.subject.localRegioselectivity-
dc.description.journalClassN-
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