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- Title
- Cytotoxicity of lignans from Lindera erytherocarpa makino
- Author(s)
- Sang Myung Lee; Seung Hwa Baek; Choong Hwan Lee; Hyang Burm Lee; Yung Hee Kho
- Bibliographic Citation
- Natural Products Sciences, vol. 8, no. 3, pp. 100-102
- Publication Year
- 2002
- Abstract
- Three lignans were isolated from a methanol extract of Lindera erytherocarpa Makino (Lauraceae) are evaluated in vitro cytotoxicity using three cancer cell line assay. The compounds were identified as methyllinderone (1), linderone (2), and kanakugiol (3) by spectroscopic methods. Amongst the compounds, methyllinderone (1) showed significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED50 values of 2.2, 2.5, 8.3 μg/ml, respectively.
- Keyword
- cytotoxicitykanakugiollindera erytherocarpa Mak.linderonemethyllinderonelindera erytherocarpacytotoxicity
- ISSN
- I000-0147
- Publisher
- Korean Society of Pharmacognosy
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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