Cytotoxicity of lignans from Lindera erytherocarpa makino

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Title
Cytotoxicity of lignans from Lindera erytherocarpa makino
Author(s)
Sang Myung Lee; Seung Hwa Baek; Choong Hwan Lee; Hyang Burm Lee; Yung Hee Kho
Bibliographic Citation
Natural Products Sciences, vol. 8, no. 3, pp. 100-102
Publication Year
2002
Abstract
Three lignans were isolated from a methanol extract of Lindera erytherocarpa Makino (Lauraceae) are evaluated in vitro cytotoxicity using three cancer cell line assay. The compounds were identified as methyllinderone (1), linderone (2), and kanakugiol (3) by spectroscopic methods. Amongst the compounds, methyllinderone (1) showed significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED50 values of 2.2, 2.5, 8.3 μg/ml, respectively.
Keyword
cytotoxicitykanakugiollindera erytherocarpa Mak.linderonemethyllinderonelindera erytherocarpacytotoxicity
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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