Chemical modification of Alisol B 23-acetate and their cytotoxic activity

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dc.contributor.authorSang Myung Lee-
dc.contributor.authorByung Sun Min-
dc.contributor.authorK H Bae-
dc.date.accessioned2017-04-19T08:59:30Z-
dc.date.available2017-04-19T08:59:30Z-
dc.date.issued2002-
dc.identifier.issn02536269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6003-
dc.description.abstractThe twelve-protostane analogues were synthesized from alisol B 23-acetate and assessed for their in vitro antitumor activity against six different human and murine tumor cell lines. of the compounds synthesized, 23S-acetoxy-24R(25)- epoxy-11β,23S-dihydroxyprotost-13(17)-en-3-hy-droxyimine (12) exhibited significant cytotoxic activities against A549, SK-OV3, B16-F10, and HT1080 tumor cells with ED50 values of 10.0, 8.7, 5.2, and 3.1 μg/ml, respectively. Furthermore, 23S-acetoxy-13(17),24R(25)-diepoxy-11β- hydroxyprotost-3-one (5), 13(17),24R(25)-diepoxy-11β, 23S- dihydroxyprotostan-3-one (6), 24R,25-epoxy-11β,23S-dihydroxyprotost-13(17)- en-3-one (7), and 11β, 23S,24R,25-tetrahydroxyprotost-13(17)-en-3-one (9) showed moderate cytotoxic activities against B16-F10 and HT1080 tumor cells. These results mean that a hydroxyimino group at C-3 position in the protostane-type terpene enhances cytotoxic activity.-
dc.publisherPharmaceutical Soc Korea-
dc.titleChemical modification of Alisol B 23-acetate and their cytotoxic activity-
dc.title.alternativeChemical modification of Alisol B 23-acetate and their cytotoxic activity-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number5-
dc.citation.endPage612-
dc.citation.startPage608-
dc.citation.volume25-
dc.contributor.alternativeName이상명-
dc.contributor.alternativeName민병선-
dc.contributor.alternativeName배기환-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 25, no. 5, pp. 608-612-
dc.identifier.doi10.1007/BF02976929-
dc.subject.keywordAlismatis Rhizoma-
dc.subject.keywordCytotoxic activity-
dc.subject.keywordProtostane-
dc.subject.localAlismatis Rhizoma-
dc.subject.localAlismatis rhizoma-
dc.subject.localCytotoxic activity-
dc.subject.localProtostane-
dc.description.journalClassY-
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