Plasma cell granuloma in cyclosporine-induced gingival overgrowth : a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-γ1

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Title
Plasma cell granuloma in cyclosporine-induced gingival overgrowth : a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-γ1
Author(s)
S S Kim; D W Eom; J R Huh; L Y Sung; In Pyo Choi; S H Ryu; P G Suh; S M Chung
Bibliographic Citation
Journal of Korean Medical Science, vol. 17, no. 5, pp. 704-707
Publication Year
2002
Abstract
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
Keyword
immunosuppressive agentphospholipase Cphospholipase C gammacase reportchemically induced disorderfemalegingiva diseasehumankidney transplantationmalemetabolism
ISSN
1011-8934
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3346/jkms.2002.17.5.704
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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