Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones

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dc.contributor.authorN H Nam-
dc.contributor.authorY Kim-
dc.contributor.authorY J You-
dc.contributor.authorDong Ho Hong-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorB Z Ahn-
dc.date.accessioned2017-04-19T08:59:32Z-
dc.date.available2017-04-19T08:59:32Z-
dc.date.issued2002-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6015-
dc.description.abstractTwo series of 2,3-diarylcyclopent-2-ene-1-ones including 2-aryl-3-(2,5-dihydroxyphenyl)cyclopent-2-ene-1-ones (2a-2f) and 3-aryl-2-(3′,4′,5′-trimethoxyphenyl)cyclopent-2-ene-1-one (3a-3j) were synthesized and evaluated for the cytotoxicity against three tumor cell lines; B16F10, HCT116 and A431. It was found that the 3,4,5-trimethoxy substituent was optimal for the bio-activity of compounds in series 2. Meanwhile, compounds in series 3 exhibited the most potent cytotoxicity with 3-aryl ring being 4-methoxyphenyl (compound 3f), (3-hydroxy-4-methoxy)phenyl (compound 3e), or (3-amino-4-methoxy)phenyl (compound 3j).-
dc.publisherPharmaceutical Soc Korea-
dc.titleSynthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones-
dc.title.alternativeSynthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones-
dc.typeArticle-
dc.citation.titleArchives of Pharmacal Research-
dc.citation.number5-
dc.citation.endPage607-
dc.citation.startPage600-
dc.citation.volume25-
dc.contributor.affiliatedAuthorDong Ho Hong-
dc.contributor.affiliatedAuthorHwan Mook Kim-
dc.contributor.alternativeName-
dc.contributor.alternativeName김용-
dc.contributor.alternativeName유영제-
dc.contributor.alternativeName홍동호-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName안병준-
dc.identifier.bibliographicCitationArchives of Pharmacal Research, vol. 25, no. 5, pp. 600-607-
dc.identifier.doi10.1007/BF02976928-
dc.subject.keyword2,3-Diarylcyclopent-2-ene-1-ones-
dc.subject.keywordantitumor activity-
dc.subject.keywordcytotoxicity-
dc.subject.local2,3-Diarylcyclopent-2-ene-1-ones-
dc.subject.localanti-tumor activity-
dc.subject.localantitumor activity-
dc.subject.localAntitumor activity-
dc.subject.localCytotoxicity-
dc.subject.localcytotoxicity-
dc.description.journalClassY-
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