Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships

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dc.contributor.authormyung sun Lee-
dc.contributor.authorWon Keun Oh-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorSoon Cheol Ahn-
dc.contributor.authorDae Ook Kang-
dc.contributor.authorC B Sohn-
dc.contributor.authorH Osada-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T08:59:32Z-
dc.date.available2017-04-19T08:59:32Z-
dc.date.issued2002-
dc.identifier.issn0032-0943-
dc.identifier.uri10.1055/s-2002-36351ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6016-
dc.description.abstractThree flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC50 = 1.1μM), dihydronorwogonin (IC50 = 2.9μM) and baicalein (IC50 = 2.4μM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.-
dc.publisherGeorg Thieme Verlag Kg-
dc.titleInhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships-
dc.title.alternativeInhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships-
dc.typeArticle-
dc.citation.titlePlanta Medica-
dc.citation.number12-
dc.citation.endPage1065-
dc.citation.startPage1063-
dc.citation.volume68-
dc.contributor.affiliatedAuthormyung sun Lee-
dc.contributor.affiliatedAuthorWon Keun Oh-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorSoon Cheol Ahn-
dc.contributor.affiliatedAuthorDae Ook Kang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName이명선-
dc.contributor.alternativeName오원근-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeName안순철-
dc.contributor.alternativeName강대욱-
dc.contributor.alternativeName손천배-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationPlanta Medica, vol. 68, no. 12, pp. 1063-1065-
dc.identifier.doi10.1055/s-2002-36351-
dc.description.journalClassY-
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Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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