DC Field | Value | Language |
---|---|---|
dc.contributor.author | myung sun Lee | - |
dc.contributor.author | Won Keun Oh | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Soon Cheol Ahn | - |
dc.contributor.author | Dae Ook Kang | - |
dc.contributor.author | C B Sohn | - |
dc.contributor.author | H Osada | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.date.accessioned | 2017-04-19T08:59:32Z | - |
dc.date.available | 2017-04-19T08:59:32Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | 10.1055/s-2002-36351 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6016 | - |
dc.description.abstract | Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC50 = 1.1μM), dihydronorwogonin (IC50 = 2.9μM) and baicalein (IC50 = 2.4μM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase. | - |
dc.publisher | Georg Thieme Verlag Kg | - |
dc.title | Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships | - |
dc.title.alternative | Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships | - |
dc.type | Article | - |
dc.citation.title | Planta Medica | - |
dc.citation.number | 12 | - |
dc.citation.endPage | 1065 | - |
dc.citation.startPage | 1063 | - |
dc.citation.volume | 68 | - |
dc.contributor.affiliatedAuthor | myung sun Lee | - |
dc.contributor.affiliatedAuthor | Won Keun Oh | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.affiliatedAuthor | Soon Cheol Ahn | - |
dc.contributor.affiliatedAuthor | Dae Ook Kang | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.alternativeName | 이명선 | - |
dc.contributor.alternativeName | 오원근 | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 안순철 | - |
dc.contributor.alternativeName | 강대욱 | - |
dc.contributor.alternativeName | 손천배 | - |
dc.contributor.alternativeName | Osada | - |
dc.contributor.alternativeName | 안종석 | - |
dc.identifier.bibliographicCitation | Planta Medica, vol. 68, no. 12, pp. 1063-1065 | - |
dc.identifier.doi | 10.1055/s-2002-36351 | - |
dc.description.journalClass | Y | - |
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