Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata

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dc.contributor.authorIn Kyoung Lee-
dc.contributor.authorBong Sik Yun-
dc.contributor.authorGyoon Hee Han-
dc.contributor.authorD H Cho-
dc.contributor.authorY H Kim-
dc.contributor.authorIck Dong Yoo-
dc.date.accessioned2017-04-19T08:59:36Z-
dc.date.available2017-04-19T08:59:36Z-
dc.date.issued2002-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6029-
dc.description.abstractIn an effort to identify neuroprotective compounds against excitatory neurotoxins from edible and medicinal mushrooms, dictyoquinazols A (1), B (2), and C (3) have been isolated from the methanolic extract of the mushroom Dictyophora indusiata. On the basis of NMR studies, their structures have been assigned as unique quinazoline compounds, which are very rare in nature. 2 and 3 existed as mixtures of rotamers (2a, 2b and 3a, 3b) inseparable by HPLC because of fast interconversion. The E/Z isomers of these compounds were assigned by comparison of 1H NMR, 13C NMR, and NOESY spectra and by 3JC.H coupling constants. Dictyoquinazols protected primary cultured mouse cortical neurons from glutamate- and NMDA-induced excitotoxicities in a dose-dependent manner.-
dc.publisherAmer Chem Soc-
dc.titleDictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata-
dc.title.alternativeDictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number12-
dc.citation.endPage1772-
dc.citation.startPage1769-
dc.citation.volume65-
dc.contributor.affiliatedAuthorIn Kyoung Lee-
dc.contributor.affiliatedAuthorBong Sik Yun-
dc.contributor.affiliatedAuthorGyoon Hee Han-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName이인경-
dc.contributor.alternativeName윤봉식-
dc.contributor.alternativeName한균희-
dc.contributor.alternativeName조덕현-
dc.contributor.alternativeName김영호-
dc.contributor.alternativeName유익동-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 65, no. 12, pp. 1769-1772-
dc.identifier.doi10.1021/np020163w-
dc.description.journalClassY-
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