Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage

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Title
Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage
Author(s)
Sung Yeon Cho; Sang Joon Park; Myung Ja Kwon; Tae Sook Jeong; Song Hae Bok; W Y Choi; W I Jeong; S Y Ryu; S H Do; C S Lee; J C Song; K S Jeong
Bibliographic Citation
Molecular and Cellular Biochemistry, vol. 243, no. 1, pp. 153-160
Publication Year
2003
Abstract
Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. Dose- and time-dependent effect of quercetin has been investigated on proinflammatory cytokine expression and NO production, focusing on its effects on the MAP kinases and the NF-κB signal transduction pathways in LPS-stimulated RAW 264.7 cells by using RT-PCR and immunoblotting. Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment. In addition, quercetin treatment inhibited NF-κB activation through stabilization of the NF-κB/IκB complex and IκB degradation and proinflammatory cytokines and NO/iNOS expression. Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-κB/IκB signal transduction pathways.
Keyword
anti-inflammationLPSMAP-kinasesNF-κBquercetin
ISSN
0300-8177
Publisher
Springer
DOI
http://dx.doi.org/10.1023/A:1021624520740
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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