Forensic value of 14 novel STRs on the human Y chromosome

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Title
Forensic value of 14 novel STRs on the human Y chromosome
Author(s)
A J Redd; A B Agellon; V A Kearney; V A Contreras; T Karafet; Hwa Yong Park; P Knijff; J M Butler; M F Hammer
Bibliographic Citation
Forensic Science International, vol. 130, no. 2, pp. 97-111
Publication Year
2002
Abstract
We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.
Keyword
DYS446DYS447DYS448DYS449DYS450DYS452DYS453DYS454DYS455DYS456DYS458DYS459DYS463DYS464Gene diversityHumansMicrosatelliteShort-Tandem-Repeat (STR)Y-chromosomeY-STR
ISSN
0379-0738
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0379-0738(02)00347-X
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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