Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract

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Title
Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract
Author(s)
N H Nam; Chang Woo Lee; Dong Ho Hong; Hwan Mook Kim; K H Bae; B Z Ahn
Bibliographic Citation
Phytotherapy Research, vol. 17, no. 1, pp. 70-76
Publication Year
2003
Abstract
A water fraction (EW), the remaining water phase from the methanol extract of Ephedra sinica after extraction with ethyl acetate and butanol, has been investigated for its antiangiogenic, antiinvasive and antitumour activities. It was observed that EW, at 30 μg/mL, a non-cytotoxic concentration, inhibited the tube formation induced by human umbilical venous endothelial cells and the invasion of B16F10 melanoma cells through a matrix membrane by more than 90%. At 30 mg/kg/day, the inhibitory activity of EW on the growth of a tumour mass in BDF1 mice inoculated with B16-F10 murine melanoma cells was comparable to that of adriamycin (ADR) administered at 2 mg/kg/day. From these results, it could be postulated that the antitumour activity of the water fraction might be attributed to its antiangiogenic and antiinvasive activities.
Keyword
Antiangiogenic activityAntiinvasive activityAntitumour activityCytotoxicityEphedra sinica
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.901
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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