Inhibitory effects of natural plant extracts on ICAM-1/LFA-1 mediated adhesion of HL-60 cells = 자생식물 추출물의 세포접착인자 저해활성 검색

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Title
Inhibitory effects of natural plant extracts on ICAM-1/LFA-1 mediated adhesion of HL-60 cells = 자생식물 추출물의 세포접착인자 저해활성 검색
Author(s)
Oh Eok Kwon; Seung Woong Lee; Mi Yeon Chung; Y H Kim; Mun Chual RhoHyun Sun Lee; Young Kook Kim
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 33, no. 4, pp. 343-351
Publication Year
2002
Abstract
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries. Monocytes/macrophages are involved in many aspects of the development of atherosclerotic plaques. It is known that the intercellular adhesion molecule-1 (ICAM-1) expressed preferentially on endothelial cells of atherosclerotic plaque, promotes local adhesion and transendothelial migration of monocytes, neutrophils, and lymphocytes. Using the human promyelocytic leukemia HL-60 cell line, we investigated the inhibitory effects of methanol extracts of 175 natural plants on ICAM-1/LFA-1 mediated cell adhesion. Eight kinds of methanol extracts of tested plants inhibited PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity at the concentration of 6.25 μg/ml. They were divided two fractions of CHCl3 and H2O to use solvent partition. Among them, CHCl3 extracts (1.0 μg/ml) of Saururus chinensis and Chloranthus japonicus significantly inhibited aggregation of HL-60 cells without cytotoxicity, respectively.
Keyword
atherosclerosiscell adhesion moleculesHL-60 cellsICAM-1plant extracts
ISSN
0253-3073
Publisher
South Korea
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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