DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | Oh Eok Kwon | - |
dc.contributor.author | Mi Yeon Chung | - |
dc.contributor.author | Y H Kim | - |
dc.contributor.author | Mun Chual Rho | - |
dc.contributor.author | Hyun Sun Lee | - |
dc.contributor.author | Young Kook Kim | - |
dc.date.accessioned | 2017-04-19T08:59:38Z | - |
dc.date.available | 2017-04-19T08:59:38Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0253-3073 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6041 | - |
dc.description.abstract | Blood monocytes are the precursors for the lipid-laden foam cells of early atherosclerotic lesions. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, and chemokine receptor 2 (CCR2) play a crucial role in the recruitment of monocytes to the vascular lesion. Using the human monocyte THP-1 cell line, we investigate the inhibitory effects of methanol extracts of 127 medicinal herbs on MCP-1-induced chemotaxis. Seven kinds of methanol extracts of medicinal herbs showed above 40% inhibitory effect with the concentration of 25 μg/ml. They were divide three fractions of CHCl3, BuOH, H2O to use solvent partition. Among them, butanol extract of Junci Medulla and CHCl3 extract of Clematidis Radix are showed significant inhibitory activities (above 50% inhibition) at the same concentration. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Screening of monocyte chemoattractant protein-1-induced chemotaxis inhibitors from medicinal herbs = 생약자원으로부터 monocyte chemoattractant protein-1에 의한 chemotaxis 저해활성 검색 | - |
dc.title.alternative | Screening of monocyte chemoattractant protein-1-induced chemotaxis inhibitors from medicinal herbs | - |
dc.type | Article | - |
dc.citation.title | Korean Journal of Pharmacognosy | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 358 | - |
dc.citation.startPage | 352 | - |
dc.citation.volume | 33 | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Oh Eok Kwon | - |
dc.contributor.affiliatedAuthor | Mi Yeon Chung | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
dc.contributor.affiliatedAuthor | Young Kook Kim | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 권오억 | - |
dc.contributor.alternativeName | 정미연 | - |
dc.contributor.alternativeName | 김영호 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.contributor.alternativeName | 이현선 | - |
dc.contributor.alternativeName | 김영국 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pharmacognosy, vol. 33, no. 4, pp. 352-358 | - |
dc.subject.keyword | chemotaxis | - |
dc.subject.keyword | medicinal herb | - |
dc.subject.keyword | monocyte chemoattractant protein-1 | - |
dc.subject.keyword | chemotaxis | - |
dc.subject.keyword | herb | - |
dc.subject.keyword | medicinal plant | - |
dc.subject.keyword | monocyte | - |
dc.subject.local | chemotaxis | - |
dc.subject.local | medicinal herb | - |
dc.subject.local | Medicinal Herb | - |
dc.subject.local | medicinal herbs | - |
dc.subject.local | Monocyte chemoattractant protein-1 | - |
dc.subject.local | monocyte chemoattractant protein-1 | - |
dc.subject.local | chemotaxis | - |
dc.subject.local | herb | - |
dc.subject.local | Herb | - |
dc.subject.local | Medicinal plants | - |
dc.subject.local | medicinal plant | - |
dc.subject.local | medicinal plants | - |
dc.subject.local | Medicinal plant | - |
dc.subject.local | Monocytes | - |
dc.subject.local | Monocyte | - |
dc.subject.local | monocyte | - |
dc.description.journalClass | N | - |
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