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- Title
- Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo
- Author(s)
- Dae Yeon Cho; Gi Hyeok Yang; Chun Jeih Ryu; Hyo Jeong Hong
- Bibliographic Citation
- Journal of Virology, vol. 77, no. 4, pp. 2784-2788
- Publication Year
- 2003
- Abstract
- The proper folding and assembly of viral envelope proteins are mediated by host chaperones. In this study, we demonstrated that an endoplasmic reticulum luminal chaperone GRP78/BiP bound specifically to the pre-S1 domain of the L protein in vitro and in vivo where complete viral particles were secreted, suggesting that GRP78/BiP plays an essential role in the proper folding of the L protein and/or assembly of viral envelope proteins.
- ISSN
- 0022-538X
- Publisher
- Amer Soc Microb
- DOI
- http://dx.doi.org/10.1128/JVI.77.4.2784-2788.2003
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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