Effect of Korea red ginseng on cerebral blood flow and superoxide production

Cited 0 time in scopus
Metadata Downloads
Title
Effect of Korea red ginseng on cerebral blood flow and superoxide production
Author(s)
C S Kim; J B Park; K J Kim; S J Chang; Sung Woo Ryoo; B H Jeon
Bibliographic Citation
Acta Pharmacologica Sinica, vol. 23, no. 12, pp. 1152-1156
Publication Year
2002
Abstract
AIM: To investigate the effects of Korea red ginseng (KRG) on the cerebral perfusion rate in the rats and the generation of superoxide anion in the endothelial cells. METHODS: The cerebral perfusion rate was measured using laser-doppler flowmetry before and after the administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the anesthetized rats. The superoxide generation was measured by the method based on lucigenin- enhanced chemiluminescence in the cultured endothelial cells. RESULTS: The relative cerebral perfusion rate (rCBF) was significantly increased by the intraperitoneal injection of CS (100 mg/kg) in the rats, but SFF had no effect on the rCBF. Chronic treatment with CS for 7 d significantly inhibited the decrease of forebrain cerebral blood flow induced by clamping both carotid arteries in the rats. Furthermore, CS (0.1 g/L) significantly suppressed NADPH-induced superoxide generation in the human umbilical vein endothelial cells (P<0.01). CONCLUSION: The present study demonstrated that crude saponin fraction of KRG enhanced cerebral blood flow in rats. Furthermore, crude saponin fraction of KRG abrogated the NADPH-driven superoxide generation in endothelial cells.
Keyword
cerebral blood flowKorean red ginsengsuperoxidesvascular endothelium
ISSN
1671-4083
Publisher
Springer-Nature Pub Group
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.