Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice

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Title
Fenofibrate improves lipid metabolism and obesity in ovariectomized LDL receptor-null mice
Author(s)
M C Yoon; S H Jeong; H H Lee; M Y Han; Joo Hyoung Kang; E Y Kim; M N Kim; Goo Taeg Oh
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 302, no. 1, pp. 29-34
Publication Year
2003
Abstract
We investigated whether fenofibrate improves lipid metabolism and obesity in female ovariectomized (OVX) or sham-operated (SO) low density lipoprotein receptor-null (LDLR-null) mice. All mice fed a high-fat diet exhibited increases in serum triglycerides and cholesterol as well as in body weight and white adipose tissue (WAT) mass compared to mice fed a low fat control diet. However, fenofibrate prevented high-fat diet-induced increases in body weight and WAT mass in female OVX LDLR-null mice, but not in SO mice. In addition, administration of fenofibrate reduced serum lipids and hepatic apolipoprotein C-III mRNA while increasing the mRNA of acyl-CoA oxidase in both groups of mice, however, these effects were more pronounced in OVX LDLR-null mice. The results of this study provide first evidence that fenofibrate improves both lipid metabolism and obesity, in part through PPARα activation, in female OVX LDLR-null mice.
Keyword
Adipose tissueBody weightFenofibrateLDLR-nullLipidPPARα
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0006-291X(03)00088-3
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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