Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis

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Title
Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis
Author(s)
I S Lee; Hyeong Kyu Lee; N T Dat; M S Lee; J W Kim; D S Na; Y H Kim
Bibliographic Citation
Planta Medica, vol. 69, no. 1, pp. 63-64
Publication Year
2003
Abstract
Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50: 1.33 ± 0.05 μM) and schisandrol A (IC50: 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50:4.73 ± 0.09 μM), schisandrin A (IC50: 7.23 ± 0.21 μM), schisandrin C (IC50: 7.54 ± 0.22 μM), benzoylisogomisin O (IC50: 11.06 ± 1.02 μM) and schisandrol B (IC50: 16.37 ± 1.00 μM).
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2003-37024
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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