Antitumor activity of flavones isolated from Artemisia argyi

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Title
Antitumor activity of flavones isolated from Artemisia argyi
Author(s)
Jeong Min Seo; Hyun Mi Kang; Kwang Hee Son; Jong Han Kim; Chang Woo Lee; Hwan Mook Kim; S I Chang; Byoung-Mog Kwon
Bibliographic Citation
Planta Medica, vol. 69, no. 3, pp. 218-222
Publication Year
2003
Abstract
The flavones 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (1), 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (2), 5-hydroxy-3′,4′,6,7-tetramethoxyflavone, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC50 values of 25-200/ μg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds I and 2 inhibited growth of a colon tumor (SW620) by 44.6% and 14.6%, respectively.
Keyword
AngiogenesisArtemisia argyiCompositaeFarnesyl protein transferaseFlavones
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2003-38486
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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