Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G(2)/M phase

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Title
Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G(2)/M phase
Author(s)
Ha Won Jeong; Dong Cho HanKwang Hee Son; Mi Young Han; Jong-Seok Lim; J H Ha; Chang Woo Lee; Hwan Mook Kim; Hyoung-Chin Kim; Byoung-Mog Kwon
Bibliographic Citation
Biochemical Pharmacology, vol. 65, no. 8, pp. 1343-1350
Publication Year
2003
Abstract
Cinnamaldehydes have been shown to have inhibitory effects on farnesyl protein transferase (FPTase; EC 2.5.1.29) in vitro, angiogenesis, cell-cell adhesion, and tumor cell growth and to be immunomodulators. However, the mechanisms responsible for these effects remain unknown. To elucidate the molecular mechanism of the cinnamaldehyde derivative CB403 for growth inhibition, CB403 was synthesized from 2′-hydroxycinnamaldehyde. CB403-treated cells were weakly adherent to the culture dishes. In addition, CB403 inhibited tumor growth in these cells in a concentration-dependent manner. FACS analysis using human cancer cells treated with this compound showed cell cycle arrest in mitosis, which was correlated with a marked increase in the amount of cyclin B1. Furthermore, CB403 blocked in vivo growth of human colon and breast tumor xenografts without loss of body weight in nude mice. These results support the hypothesis that the cinnamaldehyde derivative CB403 exerts cytostatic properties by inducing mitotic arrest in cancer cells.
Keyword
AntitumorCell cycleCinnamaldehydeCyclin
ISSN
0006-2952
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0006-2952(03)00038-8
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
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