Inhibitory effects of natural plant extracts on lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase = 자생식물 추출물의 lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase 저해활성

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Title
Inhibitory effects of natural plant extracts on lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase = 자생식물 추출물의 lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase 저해활성
Author(s)
Ha Na Yu; Kyung Hyun Cho; D E Sok; Tae Sook Jeong
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 34, no. 1, pp. 100-108
Publication Year
2003
Abstract
The regulation of plasma lipid level, particularly LDL cholesterol, represents the focus of current therapy for atherosclerosis. And Lp-PLA2 is able to hydrolyse oxidized phosphatidylcholine within LDL into lyso-PC and oxidized fatty acids. Lp-PLA2 is a potential biomarker of coronary heart disease and plays an important proinflammatory role in the progression of atherosclerosis. We investigated the inhibitory effects of methanol extracts of 224 natural plants on Lp-PLA2 activity. Seven kinds of methanol extracts of tested plants showed above 50% inhibitory effect with the concentration of 100 μg/ml. The concentrated aqueous suspensions of each methanol extract were partitioned with n-hexane, CHCl3, and EtOAc. Among them, EtOAc extracts of Astilbe chinensis var. davidii (root) and Pourthiaea villosa var. brunnea (leaf) significantly inhibited Lp-PLA2 activity at the same concentration.
Keyword
atherosclerosisinflammationLp-PLA2oxidized LDLplant extracts
ISSN
0253-3073
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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