Dykellic acid inhibits drug-induced caspase-3-like protease activation

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dc.contributor.authorSang-Han Lee-
dc.contributor.authorEun Soo Youk-
dc.contributor.authorHo Jae Lee-
dc.contributor.authorYung Hee Kho-
dc.contributor.authorHwan Mook Kim-
dc.contributor.authorSung Uk Kim-
dc.date.accessioned2017-04-19T08:59:49Z-
dc.date.available2017-04-19T08:59:49Z-
dc.date.issued2003-
dc.identifier.issn0006291X-
dc.identifier.uri10.1016/S0006-291X(03)00210-9ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6104-
dc.description.abstractDykellic acid is a novel microbial metabolite isolated from the broth of Westerdykella multispora F50733. Investigations on the molecular function of dykellic acid revealed that this compound partially inhibits calcium influx, resulting in a decrease in Ca2+-dependent endonuclease activation and DNA fragmentation induced by camptothecin. In our experiments, active caspase-3-like protease cleavage of procaspase-3, PARP, and cytosolic cytochrome c was inhibited by dykellic acid in a concentration-dependent manner when the apoptosis was induced by camptothecin as well as doxorubicin. We confirmed that dykellic acid did not bind to camptothecin using surface plasmon resonance analysis. These results suggest that dykellic acid inhibits drug-induced apoptosis via a caspase-3-like protease-suppressing mechanism. Our data provide important information on the mechanism of action of dykellic acid and indicate that this compound may be employed in the treatment of specific caspase-3-like protease-mediated diseases.-
dc.publisherElsevier-
dc.titleDykellic acid inhibits drug-induced caspase-3-like protease activation-
dc.title.alternativeDykellic acid inhibits drug-induced caspase-3-like protease activation-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number3-
dc.citation.endPage544-
dc.citation.startPage539-
dc.citation.volume302-
dc.contributor.alternativeName이상한-
dc.contributor.alternativeName육은수-
dc.contributor.alternativeName이호재-
dc.contributor.alternativeName고영희-
dc.contributor.alternativeName김환묵-
dc.contributor.alternativeName김성욱-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 302, no. 3, pp. 539-544-
dc.identifier.doi10.1016/S0006-291X(03)00210-9-
dc.subject.keywordApoptosis inhibitor-
dc.subject.keywordCamptothecin-
dc.subject.keywordCaspase-3-like protease-
dc.subject.keywordDykellic acid-
dc.subject.keywordInhibitor-
dc.subject.localApoptosis inhibitor-
dc.subject.localCamptothecin-
dc.subject.localCaspase-3-like protease-
dc.subject.localDykellic acid-
dc.subject.localInhibitor-
dc.description.journalClassY-
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